Eight International London Cough Symposium 2014: Cough hypersensitivity syndrome as the basis for chronic cough

Kian Fan Chung, Brendan J Canning, Lorcan McGarvey

Research output: Contribution to journalArticle

Abstract

At the Eighth International London Cough Conference held in London in July 2014, the focus was on the relatively novel concept of cough hypersensitivity syndrome (CHS) as forming the basis of chronic cough. This concept has been formulated following understanding of the neuronal pathways for cough and a realisation that not all chronic cough is usually associated with a cause. The CHS is defined by troublesome coughing triggered by low level of thermal, mechanical or chemical exposure. It also encompasses other symptoms or sensations such as laryngeal hypersensitivity, nasal hypersensitivity and possibly also symptoms related to gastrooesopahgeal reflux. The pathophysiologic basis of the CHS is now being increasingly linked to an enhancement of the afferent pathways of the cough reflex both at the peripheral and central levels. Mechanisms involved include the interactions of inflammatory mechanisms with cough sensors in the upper airways and with neuronal pathways of cough, associated with a central component. Tools for assessing CHS in the clinic need to be developed. New drugs may be developed to control CHS. A roadmap is suggested from the inception of the CHS concept towards the development of newer antitussives at the Symposium.

Original languageEnglish (US)
Pages (from-to)76-80
Number of pages5
JournalPulmonary Pharmacology and Therapeutics
Volume35
DOIs
StatePublished - 2015

Fingerprint

Antitussive Agents
Cough
Hypersensitivity
Sensors
Pharmaceutical Preparations
Hot Temperature
Afferent Pathways
Nose

Keywords

  • Amitryptiline
  • Antitussives
  • Chronic cough
  • Cough hypersensitivity syndrome
  • Gabapentin
  • Laryngeal hypersensitivity
  • Neural pathways
  • Neuroinflammation
  • P2X2/3 receptors
  • TRPA1
  • TRPV1

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Pharmacology (medical)
  • Biochemistry, medical

Cite this

Eight International London Cough Symposium 2014 : Cough hypersensitivity syndrome as the basis for chronic cough. / Chung, Kian Fan; Canning, Brendan J; McGarvey, Lorcan.

In: Pulmonary Pharmacology and Therapeutics, Vol. 35, 2015, p. 76-80.

Research output: Contribution to journalArticle

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