Egocentric coding of external items in the lateral entorhinal cortex

Cheng Wang, Xiaojing Chen, Heekyung Lee, Sachin S. Deshmukh, D. Yoganarasimha, Francesco Savelli, James J. Knierim

Research output: Contribution to journalArticlepeer-review

Abstract

Episodic memory, the conscious recollection of past events, is typically experienced from a first-person (egocentric) perspective. The hippocampus plays an essential role in episodic memory and spatial cognition. Although the allocentric nature of hippocampal spatial coding is well understood, little is known about whether the hippocampus receives egocentric information about external items.We recorded in rats the activity of single neurons from the lateral entorhinal cortex (LEC) and medial entorhinal cortex (MEC), the two major inputs to the hippocampus. Many LEC neurons showed tuning for egocentric bearing of external items, whereas MEC cells tended to represent allocentric bearing. These results demonstrate a fundamental dissociation between the reference frames of LEC and MEC neural representations.

Original languageEnglish (US)
Pages (from-to)945-949
Number of pages5
JournalScience
Volume362
Issue number6417
DOIs
StatePublished - Nov 23 2018

ASJC Scopus subject areas

  • General

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