Efflux inhibition with verapamil potentiates bedaquiline in mycobacterium tuberculosis

Shashank Gupta, Keira A. Cohen, Kathryn Winglee, Mamoudou Maiga, Bassirou Diarra, William R. Bishai

Research output: Contribution to journalArticlepeer-review


Drug efflux is an important resistance mechanism in Mycobacterium tuberculosis. We found that verapamil, an efflux inhibitor, profoundly decreases the MIC of bedaquiline and clofazimine to M. tuberculosis by 8- to 16-fold. This exquisite susceptibility was noted among drug-susceptible and drug-resistant clinical isolates. Thus, efflux inhibition is an important sensitizer of bedaquiline and clofazimine, and efflux may emerge as a resistance mechanism to these drugs.

Original languageEnglish (US)
Pages (from-to)574-576
Number of pages3
JournalAntimicrobial agents and chemotherapy
Issue number1
StatePublished - Jan 2014

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases


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