Efflux inhibition with verapamil potentiates bedaquiline in mycobacterium tuberculosis

Shashank Gupta, Keira Cohen, Kathryn Winglee, Mamoudou Maiga, Bassirou Diarra, William Ramses Bishai

Research output: Contribution to journalArticle

Abstract

Drug efflux is an important resistance mechanism in Mycobacterium tuberculosis. We found that verapamil, an efflux inhibitor, profoundly decreases the MIC of bedaquiline and clofazimine to M. tuberculosis by 8- to 16-fold. This exquisite susceptibility was noted among drug-susceptible and drug-resistant clinical isolates. Thus, efflux inhibition is an important sensitizer of bedaquiline and clofazimine, and efflux may emerge as a resistance mechanism to these drugs.

Original languageEnglish (US)
Pages (from-to)574-576
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume58
Issue number1
DOIs
StatePublished - Jan 2014

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bedaquiline
Verapamil
Mycobacterium tuberculosis
Clofazimine
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

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Efflux inhibition with verapamil potentiates bedaquiline in mycobacterium tuberculosis. / Gupta, Shashank; Cohen, Keira; Winglee, Kathryn; Maiga, Mamoudou; Diarra, Bassirou; Bishai, William Ramses.

In: Antimicrobial Agents and Chemotherapy, Vol. 58, No. 1, 01.2014, p. 574-576.

Research output: Contribution to journalArticle

Gupta, Shashank ; Cohen, Keira ; Winglee, Kathryn ; Maiga, Mamoudou ; Diarra, Bassirou ; Bishai, William Ramses. / Efflux inhibition with verapamil potentiates bedaquiline in mycobacterium tuberculosis. In: Antimicrobial Agents and Chemotherapy. 2014 ; Vol. 58, No. 1. pp. 574-576.
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