Efficient synthesis of phosphorylated prodrugs with bis(POM)-phosphoryl chloride

Yousang Hwang; Philip A. Cole

doi:10.1021/ol049714v

Efficient synthesis of phosphorylated prodrugs with bis(POM)-phosphoryl chloride

Yousang Hwang, Philip A. Cole

School of Medicine

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

An efficient method for the synthesis of phosphorylated prodrugs is described. The preparation of various bis-pivaloyloxymethyl (POM) phosphate triesters was accomplished in moderate to good yields with the use of bis(POM) phosphoryl chloride under mild conditions.

Original language	English (US)
Pages (from-to)	1555-1556
Number of pages	2
Journal	Organic Letters
Volume	6
Issue number	10
DOIs	https://doi.org/10.1021/ol049714v
State	Published - May 13 2004

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol049714v

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title = "Efficient synthesis of phosphorylated prodrugs with bis(POM)-phosphoryl chloride",

abstract = "An efficient method for the synthesis of phosphorylated prodrugs is described. The preparation of various bis-pivaloyloxymethyl (POM) phosphate triesters was accomplished in moderate to good yields with the use of bis(POM) phosphoryl chloride under mild conditions.",

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AU - Cole, Philip A.

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AB - An efficient method for the synthesis of phosphorylated prodrugs is described. The preparation of various bis-pivaloyloxymethyl (POM) phosphate triesters was accomplished in moderate to good yields with the use of bis(POM) phosphoryl chloride under mild conditions.

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Efficient synthesis of phosphorylated prodrugs with bis(POM)-phosphoryl chloride

Abstract

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