Efficient synthesis of phosphorylated prodrugs with bis(POM)-phosphoryl chloride

You Sang Hwang, Philip A. Cole

Research output: Contribution to journalArticle

Abstract

An efficient method for the synthesis of phosphorylated prodrugs is described. The preparation of various bis-pivaloyloxymethyl (POM) phosphate triesters was accomplished in moderate to good yields with the use of bis(POM) phosphoryl chloride under mild conditions.

Original languageEnglish (US)
Pages (from-to)1555-1556
Number of pages2
JournalOrganic Letters
Volume6
Issue number10
DOIs
StatePublished - May 13 2004

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Prodrugs
phosphates
chlorides
preparation
synthesis
bis-pivaloyloxymethyl phosphate
phosphoryl chloride

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Efficient synthesis of phosphorylated prodrugs with bis(POM)-phosphoryl chloride. / Hwang, You Sang; Cole, Philip A.

In: Organic Letters, Vol. 6, No. 10, 13.05.2004, p. 1555-1556.

Research output: Contribution to journalArticle

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