Efficient synthesis of phosphorylated prodrugs with bis(POM)-phosphoryl chloride

Yousang Hwang, Philip A. Cole

Research output: Contribution to journalArticlepeer-review

Abstract

An efficient method for the synthesis of phosphorylated prodrugs is described. The preparation of various bis-pivaloyloxymethyl (POM) phosphate triesters was accomplished in moderate to good yields with the use of bis(POM) phosphoryl chloride under mild conditions.

Original languageEnglish (US)
Pages (from-to)1555-1556
Number of pages2
JournalOrganic Letters
Volume6
Issue number10
DOIs
StatePublished - May 13 2004

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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