Efficient simulation of epistatic interactions in case-parent trios

Research output: Contribution to journalArticle

Abstract

Statistical approaches to evaluate interactions between single nucleotide polymorphisms (SNPs) and SNP-environment interactions are of great importance in genetic association studies, as susceptibility to complex disease might be related to the interaction of multiple SNPs and/or environmental factors. With these methods under active development, algorithms to simulate genomic data sets are needed to ensure proper type I error control of newly proposed methods and to compare power with existing methods. In this paper we propose an efficient method for a haplotype-based simulation of case-parent trios when the disease risk is thought to depend on possibly higher-order epistatic interactions or gene-environment interactions with binary exposures.

Original languageEnglish (US)
Pages (from-to)12-22
Number of pages11
JournalHuman Heredity
Volume75
Issue number1
DOIs
StatePublished - May 2013

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Single Nucleotide Polymorphism
Gene-Environment Interaction
Genetic Association Studies
Haplotypes
Datasets

Keywords

  • Case-parent trios
  • Haplotypes
  • Interactions
  • Single nucleotide polymorphisms

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Efficient simulation of epistatic interactions in case-parent trios. / Li, Qing; Schwender, Holger; Louis, Thomas; Fallin, Daniele Daniele; Ruczinski, Ingo.

In: Human Heredity, Vol. 75, No. 1, 05.2013, p. 12-22.

Research output: Contribution to journalArticle

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