Efficient parallel synthesis of macrocyclic peptidomimetics

Eric Marsault, Hamid R. Hoveyda, René Gagnon, Mark L. Peterson, Martin Vézina, Carl Saint-Louis, Annick Landry, Jean François Pinault, Luc Ouellet, Sophie Beauchemin, Sylvie Beaubien, Axel Mathieu, Kamel Benakli, Zhigang Wang, Martin Brassard, David Lonergan, François Bilodeau, Mahesh Ramaseshan, Nadia Fortin, Ruoxi LanShigui Li, Fabrice Galaud, Véronique Plourde, Manon Champagne, Annie Doucet, Patrick Bhérer, Maude Gauthier, Gilles Olsen, Gérald Villeneuve, Shridhar Bhat, Laurence Foucher, Daniel Fortin, Xiaowen Peng, Sylvain Bernard, Alexandre Drouin, Robert Déziel, Gilles Berthiaume, Yves L. Dory, Graeme L. Fraser, Pierre Deslongchamps

Research output: Contribution to journalArticle

Abstract

A new method for solid phase parallel synthesis of chemically and conformationally diverse macrocyclic peptidomimetics is reported. A key feature of the method is access to broad chemical and conformational diversity. Synthesis and mechanistic studies on the macrocyclization step are reported.

Original languageEnglish (US)
Pages (from-to)4731-4735
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number16
DOIs
StatePublished - Aug 15 2008
Externally publishedYes

Keywords

  • Macrocycle
  • Peptidomimetic
  • Solid phase synthesis
  • Tether

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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