Efficient induction of protective anti-malaria immunity by recombinant adenovirus

Elaine G. Rodrigues, Fidel Zavala, Ruth S. Nussenzweig, James M. Wilson, Moriya Tsuji

Research output: Contribution to journalArticlepeer-review

Abstract

The immunogenicity of a previously constructed replication-defective recombinant adenovirus expressing the CS protein of Plasmodium yoelii was compared with that of irradiated sporozoites. We found that immunization of BALB/c mice with a single dose of this recombinant adenovirus induced a much greater CS-specific T-cell response compared with immunization with irradiated sporozoites. More importantly, we found that this recombinant adenovirus induces similar or higher levels of protective immunity than those induced by irradiated sporozoites, eliciting an appreciable resistance to malaria infection.

Original languageEnglish (US)
Pages (from-to)1812-1817
Number of pages6
JournalVaccine
Volume16
Issue number19
DOIs
StatePublished - Nov 1998
Externally publishedYes

Keywords

  • Adenovirus
  • Malaria
  • Protection

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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