Efficacy of zidovudine and human immunodeficiency virus (HIV) hyperimmune immunoglobulin for reducing perinatal HIV transmission from HIV- infected women with advanced disease: Results of pediatric AIDS clinical trials group protocol 185

E. Richard Stiehm, John S. Lambert, Lynne M. Mofenson, James Bethel, Jean Whitehouse, Robert Nugent, Moye John, Mary Glenn Fowler, Bonnie J. Mathieson, Patricia Reichelderfer, George J. Nemo, James Korelitz, William A. Meyer, Christine V. Sapan, Eleanor Jimenez, Jorge Gandia, Gwendolyn Scott, Mary Jo O'Sullivan, Andrea Kovacs, Alice StekWilliam T. Shearer, Hunter Hammill

Research output: Contribution to journalArticle

Abstract

Pediatric AIDS Clinical Trials Group protocol 185 evaluated whether zidovudine combined with human immunodeficiency virus (HIV) hyperimmune immunoglobulin (HIVIG) infusions administered monthly during pregnancy and to the neonate at birth would significantly lower perinatal HIV transmission compared with treatment with zidovudine and intravenous immunoglobulin (IVIG) without HIV antibody. Subjects had baseline CD4 cell counts ≤500/ μL (22% had counts

Original languageEnglish (US)
Pages (from-to)567-575
Number of pages9
JournalJournal of Infectious Diseases
Volume179
Issue number3
DOIs
StatePublished - 1999
Externally publishedYes

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Zidovudine
Clinical Protocols
Immunoglobulins
Acquired Immunodeficiency Syndrome
Clinical Trials
HIV
Pediatrics
Intravenous Immunoglobulins
CD4 Lymphocyte Count
Parturition
Newborn Infant
Pregnancy
Antibodies
Therapeutics

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Efficacy of zidovudine and human immunodeficiency virus (HIV) hyperimmune immunoglobulin for reducing perinatal HIV transmission from HIV- infected women with advanced disease : Results of pediatric AIDS clinical trials group protocol 185. / Stiehm, E. Richard; Lambert, John S.; Mofenson, Lynne M.; Bethel, James; Whitehouse, Jean; Nugent, Robert; John, Moye; Fowler, Mary Glenn; Mathieson, Bonnie J.; Reichelderfer, Patricia; Nemo, George J.; Korelitz, James; Meyer, William A.; Sapan, Christine V.; Jimenez, Eleanor; Gandia, Jorge; Scott, Gwendolyn; O'Sullivan, Mary Jo; Kovacs, Andrea; Stek, Alice; Shearer, William T.; Hammill, Hunter.

In: Journal of Infectious Diseases, Vol. 179, No. 3, 1999, p. 567-575.

Research output: Contribution to journalArticle

Stiehm, ER, Lambert, JS, Mofenson, LM, Bethel, J, Whitehouse, J, Nugent, R, John, M, Fowler, MG, Mathieson, BJ, Reichelderfer, P, Nemo, GJ, Korelitz, J, Meyer, WA, Sapan, CV, Jimenez, E, Gandia, J, Scott, G, O'Sullivan, MJ, Kovacs, A, Stek, A, Shearer, WT & Hammill, H 1999, 'Efficacy of zidovudine and human immunodeficiency virus (HIV) hyperimmune immunoglobulin for reducing perinatal HIV transmission from HIV- infected women with advanced disease: Results of pediatric AIDS clinical trials group protocol 185', Journal of Infectious Diseases, vol. 179, no. 3, pp. 567-575. https://doi.org/10.1086/314637
Stiehm, E. Richard ; Lambert, John S. ; Mofenson, Lynne M. ; Bethel, James ; Whitehouse, Jean ; Nugent, Robert ; John, Moye ; Fowler, Mary Glenn ; Mathieson, Bonnie J. ; Reichelderfer, Patricia ; Nemo, George J. ; Korelitz, James ; Meyer, William A. ; Sapan, Christine V. ; Jimenez, Eleanor ; Gandia, Jorge ; Scott, Gwendolyn ; O'Sullivan, Mary Jo ; Kovacs, Andrea ; Stek, Alice ; Shearer, William T. ; Hammill, Hunter. / Efficacy of zidovudine and human immunodeficiency virus (HIV) hyperimmune immunoglobulin for reducing perinatal HIV transmission from HIV- infected women with advanced disease : Results of pediatric AIDS clinical trials group protocol 185. In: Journal of Infectious Diseases. 1999 ; Vol. 179, No. 3. pp. 567-575.
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abstract = "Pediatric AIDS Clinical Trials Group protocol 185 evaluated whether zidovudine combined with human immunodeficiency virus (HIV) hyperimmune immunoglobulin (HIVIG) infusions administered monthly during pregnancy and to the neonate at birth would significantly lower perinatal HIV transmission compared with treatment with zidovudine and intravenous immunoglobulin (IVIG) without HIV antibody. Subjects had baseline CD4 cell counts ≤500/ μL (22{\%} had counts",
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AU - Nugent, Robert

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AU - Gandia, Jorge

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AU - Stek, Alice

AU - Shearer, William T.

AU - Hammill, Hunter

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