Efficacy of the lipid-soluble iron chelator 2,2'-dipyridyl against hemorrhagic brain injury

He Wu, Tao Wu, Mingchang Li, Jian Wang

Research output: Contribution to journalArticlepeer-review

Abstract

Previous studies have indicated that 2,2'-dipyridyl, a lipid-soluble ferrous iron chelator, can reduce brain injury after cerebral ischemia and reduce cerebral vasospasm after subarachnoid hemorrhage. In this study, we examined the efficacy of 2,2'-dipyridyl after intracerebral hemorrhage (ICH) in 12-month-old mice. ICH was modeled by intrastriatal injection of collagenase or autologous whole blood. 2,2'-Dipyridyl or vehicle was administered intraperitoneally 2. h before ICH (pretreatment) or 6. h after ICH (post-treatment) and then once daily for up to 3. days. Mice in the pretreatment group were sacrificed 1 or 3. days after ICH and examined for iron deposition, neuronal death, oxidative stress, microglial/astrocyte activation, neutrophil infiltration, and white matter damage. Mice in the post-treatment group were examined for brain lesion volume and edema on day 3 and for neurologic deficits on days 1, 3, and 28 after ICH. Pretreatment with 2,2'-dipyridyl decreased iron accumulation and neuronal death, attenuated production of reactive oxygen species, reduced microglial activation without affecting astrocytes or neutrophil infiltration, and attenuated white matter damage. Post-treatment reduced brain lesion volume and edema and improved neurologic function. These results indicate that the lipid-soluble ferrous iron chelator 2,2'-dipyridyl can reduce brain injury and improve functional outcome after ICH.

Original languageEnglish (US)
Pages (from-to)388-394
Number of pages7
JournalNeurobiology of Disease
Volume45
Issue number1
DOIs
StatePublished - Jan 2012

Keywords

  • 2,2'-dipyridyl
  • Intracerebral hemorrhage
  • Iron
  • Neuronal death
  • White matter

ASJC Scopus subject areas

  • Neurology

Fingerprint

Dive into the research topics of 'Efficacy of the lipid-soluble iron chelator 2,2'-dipyridyl against hemorrhagic brain injury'. Together they form a unique fingerprint.

Cite this