Efficacy of sulfadoxine-pyrimethamine as first line treatment for malaria declining in Malawi

Research output: Contribution to journalComment/debatepeer-review

Abstract

Question: After 10 years as the first-line antimalarial drug, has sulfadoxine-pyrimethamine retained efficacy in Malawi? Study design: Prospective cohort study. Main results: Outcomes measured at 14 days: over 5 years, adequate clinical response rates remained above 80% but parasitological responses significantly decreased (see Results table). Outcomes measured at 28 days: adequate clinical response rates decreased over 5 years (73% to 60%). Parasitological response rates also declined. Authors' conclusions: The rates of parasite clearance declined during the study, suggesting that other treatments should be investigated.

Original languageEnglish (US)
Pages (from-to)280-283
Number of pages4
JournalEvidence-Based Healthcare and Public Health
Volume8
Issue number5
DOIs
StatePublished - Oct 2004

Keywords

  • Cohort study
  • Drug resistance
  • Malaria
  • Malawi
  • Sulfadoxine-pyrimethamine
  • Treatment outcome

ASJC Scopus subject areas

  • Medicine(all)

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