Efficacy of oral zinc supplementation in radiologically confirmed pneumonia: Secondary analysis of a randomized controlled trial

Narendra Kumar Bagri; Neha Bagri; Manisha Jana; Arun Kumar Gupta; Nitya Wadhwa; Rakesh Lodha; Sushil Kumar Kabra; Aruna Chandran; Satinder Aneja; Mona K. Chaturvedi; Jitender Sodhi; Sean Patrick Fitzwater; Jagdish Chandra; Bimbadhar Rath; Udaypal S. Kainth; Savita Saini; Robert E. Black; Mathuram Santosham; Shinjini Bhatnagar

doi:10.1093/tropej/fmx036

Efficacy of oral zinc supplementation in radiologically confirmed pneumonia: Secondary analysis of a randomized controlled trial

Narendra Kumar Bagri, Neha Bagri, Manisha Jana, Arun Kumar Gupta, Nitya Wadhwa, Rakesh Lodha, Sushil Kumar Kabra, Aruna Chandran, Satinder Aneja, Mona K. Chaturvedi, Jitender Sodhi, Sean Patrick Fitzwater, Jagdish Chandra, Bimbadhar Rath, Udaypal S. Kainth, Savita Saini, Robert E. Black, Mathuram Santosham, Shinjini Bhatnagar

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Objective: To evaluate the effect of zinc as an adjuvant therapy in radiologically confirmed pneumonia in children 2-24 months of age. Patients and Methods: We analyzed data of 212 children with pneumonia for whom chest X-ray films were available at enrollment and at least two radiologists agreed on the diagnosis of pneumonia. We compared the time to recovery in the two groups (n=121, zinc group and n=91, placebo group) using a Cox proportional hazards regression model. Results: Time to recovery was similar in both groups [median interquartile range: zinc, 84 h (64, 140 h); placebo, 85 h (65, 140 h)]. The absolute risk reduction for treatment failure was 5.2% (95% confidence interval: -4.8, 15.1) with zinc supplementation. Conclusion: There was no significant beneficial effect of zinc on the duration of recovery or risk of treatment failure in children with radiologically confirmed pneumonia.

Original language	English (US)
Pages (from-to)	110-117
Number of pages	8
Journal	Journal of tropical pediatrics
Volume	64
Issue number	2
DOIs	https://doi.org/10.1093/tropej/fmx036
State	Published - Apr 1 2018

Keywords

Chest X-ray
Children
Radiological pneumonia
Zinc

ASJC Scopus subject areas

General Medicine

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10.1093/tropej/fmx036

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Bagri, N. K., Bagri, N., Jana, M., Gupta, A. K., Wadhwa, N., Lodha, R., Kabra, S. K., Chandran, A., Aneja, S., Chaturvedi, M. K., Sodhi, J., Fitzwater, S. P., Chandra, J., Rath, B., Kainth, U. S., Saini, S., Black, R. E., Santosham, M., & Bhatnagar, S. (2018). Efficacy of oral zinc supplementation in radiologically confirmed pneumonia: Secondary analysis of a randomized controlled trial. Journal of tropical pediatrics, 64(2), 110-117. https://doi.org/10.1093/tropej/fmx036

Bagri, NK, Bagri, N, Jana, M, Gupta, AK, Wadhwa, N, Lodha, R, Kabra, SK, Chandran, A, Aneja, S, Chaturvedi, MK, Sodhi, J, Fitzwater, SP, Chandra, J, Rath, B, Kainth, US, Saini, S, Black, RE , Santosham, M & Bhatnagar, S 2018, 'Efficacy of oral zinc supplementation in radiologically confirmed pneumonia: Secondary analysis of a randomized controlled trial', Journal of tropical pediatrics, vol. 64, no. 2, pp. 110-117. https://doi.org/10.1093/tropej/fmx036

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abstract = "Objective: To evaluate the effect of zinc as an adjuvant therapy in radiologically confirmed pneumonia in children 2-24 months of age. Patients and Methods: We analyzed data of 212 children with pneumonia for whom chest X-ray films were available at enrollment and at least two radiologists agreed on the diagnosis of pneumonia. We compared the time to recovery in the two groups (n=121, zinc group and n=91, placebo group) using a Cox proportional hazards regression model. Results: Time to recovery was similar in both groups [median interquartile range: zinc, 84 h (64, 140 h); placebo, 85 h (65, 140 h)]. The absolute risk reduction for treatment failure was 5.2% (95% confidence interval: -4.8, 15.1) with zinc supplementation. Conclusion: There was no significant beneficial effect of zinc on the duration of recovery or risk of treatment failure in children with radiologically confirmed pneumonia.",

keywords = "Chest X-ray, Children, Radiological pneumonia, Zinc",

author = "Bagri, {Narendra Kumar} and Neha Bagri and Manisha Jana and Gupta, {Arun Kumar} and Nitya Wadhwa and Rakesh Lodha and Kabra, {Sushil Kumar} and Aruna Chandran and Satinder Aneja and Chaturvedi, {Mona K.} and Jitender Sodhi and Fitzwater, {Sean Patrick} and Jagdish Chandra and Bimbadhar Rath and Kainth, {Udaypal S.} and Savita Saini and Black, {Robert E.} and Mathuram Santosham and Shinjini Bhatnagar",

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doi = "10.1093/tropej/fmx036",

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T1 - Efficacy of oral zinc supplementation in radiologically confirmed pneumonia

T2 - Secondary analysis of a randomized controlled trial

AU - Bagri, Narendra Kumar

AU - Bagri, Neha

AU - Jana, Manisha

AU - Gupta, Arun Kumar

AU - Wadhwa, Nitya

AU - Lodha, Rakesh

AU - Kabra, Sushil Kumar

AU - Chandran, Aruna

AU - Aneja, Satinder

AU - Chaturvedi, Mona K.

AU - Sodhi, Jitender

AU - Fitzwater, Sean Patrick

AU - Chandra, Jagdish

AU - Rath, Bimbadhar

AU - Kainth, Udaypal S.

AU - Saini, Savita

AU - Black, Robert E.

AU - Santosham, Mathuram

AU - Bhatnagar, Shinjini

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Objective: To evaluate the effect of zinc as an adjuvant therapy in radiologically confirmed pneumonia in children 2-24 months of age. Patients and Methods: We analyzed data of 212 children with pneumonia for whom chest X-ray films were available at enrollment and at least two radiologists agreed on the diagnosis of pneumonia. We compared the time to recovery in the two groups (n=121, zinc group and n=91, placebo group) using a Cox proportional hazards regression model. Results: Time to recovery was similar in both groups [median interquartile range: zinc, 84 h (64, 140 h); placebo, 85 h (65, 140 h)]. The absolute risk reduction for treatment failure was 5.2% (95% confidence interval: -4.8, 15.1) with zinc supplementation. Conclusion: There was no significant beneficial effect of zinc on the duration of recovery or risk of treatment failure in children with radiologically confirmed pneumonia.

AB - Objective: To evaluate the effect of zinc as an adjuvant therapy in radiologically confirmed pneumonia in children 2-24 months of age. Patients and Methods: We analyzed data of 212 children with pneumonia for whom chest X-ray films were available at enrollment and at least two radiologists agreed on the diagnosis of pneumonia. We compared the time to recovery in the two groups (n=121, zinc group and n=91, placebo group) using a Cox proportional hazards regression model. Results: Time to recovery was similar in both groups [median interquartile range: zinc, 84 h (64, 140 h); placebo, 85 h (65, 140 h)]. The absolute risk reduction for treatment failure was 5.2% (95% confidence interval: -4.8, 15.1) with zinc supplementation. Conclusion: There was no significant beneficial effect of zinc on the duration of recovery or risk of treatment failure in children with radiologically confirmed pneumonia.

KW - Chest X-ray

KW - Children

KW - Radiological pneumonia

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Efficacy of oral zinc supplementation in radiologically confirmed pneumonia: Secondary analysis of a randomized controlled trial

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