Efficacy of oral zinc supplementation in radiologically confirmed pneumonia: Secondary analysis of a randomized controlled trial

Narendra Kumar Bagri, Neha Bagri, Manisha Jana, Arun Kumar Gupta, Nitya Wadhwa, Rakesh Lodha, Sushil Kumar Kabra, Aruna Chandran, Satinder Aneja, Mona K. Chaturvedi, Jitender Sodhi, Sean PATRICK Fitzwater, Jagdish Chandra, Bimbadhar Rath, Udaypal S. Kainth, Savita Saini, Robert E. Black, Mathuram Santosham, Shinjini Bhatnagar

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the effect of zinc as an adjuvant therapy in radiologically confirmed pneumonia in children 2-24 months of age. Patients and Methods: We analyzed data of 212 children with pneumonia for whom chest X-ray films were available at enrollment and at least two radiologists agreed on the diagnosis of pneumonia. We compared the time to recovery in the two groups (n=121, zinc group and n=91, placebo group) using a Cox proportional hazards regression model. Results: Time to recovery was similar in both groups [median interquartile range: zinc, 84 h (64, 140 h); placebo, 85 h (65, 140 h)]. The absolute risk reduction for treatment failure was 5.2% (95% confidence interval: -4.8, 15.1) with zinc supplementation. Conclusion: There was no significant beneficial effect of zinc on the duration of recovery or risk of treatment failure in children with radiologically confirmed pneumonia.

Original languageEnglish (US)
Pages (from-to)110-117
Number of pages8
JournalJournal of Tropical Pediatrics
Volume64
Issue number2
DOIs
StatePublished - Apr 1 2018

Keywords

  • Chest X-ray
  • Children
  • Radiological pneumonia
  • Zinc

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases

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