Efficacy of oral zinc supplementation in radiologically confirmed pneumonia: Secondary analysis of a randomized controlled trial

Narendra Kumar Bagri, Neha Bagri, Manisha Jana, Arun Kumar Gupta, Nitya Wadhwa, Rakesh Lodha, Sushil Kumar Kabra, Aruna Chandran, Satinder Aneja, Mona K. Chaturvedi, Jitender Sodhi, Sean Patrick Fitzwater, Jagdish Chandra, Bimbadhar Rath, Udaypal S. Kainth, Savita Saini, Robert E Black, Mathuram Santosham, Shinjini Bhatnagar

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the effect of zinc as an adjuvant therapy in radiologically confirmed pneumonia in children 2-24 months of age. Patients and Methods: We analyzed data of 212 children with pneumonia for whom chest X-ray films were available at enrollment and at least two radiologists agreed on the diagnosis of pneumonia. We compared the time to recovery in the two groups (n=121, zinc group and n=91, placebo group) using a Cox proportional hazards regression model. Results: Time to recovery was similar in both groups [median interquartile range: zinc, 84 h (64, 140 h); placebo, 85 h (65, 140 h)]. The absolute risk reduction for treatment failure was 5.2% (95% confidence interval: -4.8, 15.1) with zinc supplementation. Conclusion: There was no significant beneficial effect of zinc on the duration of recovery or risk of treatment failure in children with radiologically confirmed pneumonia.

Original languageEnglish (US)
Pages (from-to)110-117
Number of pages8
JournalJournal of Tropical Pediatrics
Volume64
Issue number2
DOIs
StatePublished - Apr 1 2018

Fingerprint

Zinc
Pneumonia
Randomized Controlled Trials
Treatment Failure
Placebos
Numbers Needed To Treat
X-Ray Film
Proportional Hazards Models
Thorax
Confidence Intervals
Therapeutics

Keywords

  • Chest X-ray
  • Children
  • Radiological pneumonia
  • Zinc

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases

Cite this

Efficacy of oral zinc supplementation in radiologically confirmed pneumonia : Secondary analysis of a randomized controlled trial. / Bagri, Narendra Kumar; Bagri, Neha; Jana, Manisha; Gupta, Arun Kumar; Wadhwa, Nitya; Lodha, Rakesh; Kabra, Sushil Kumar; Chandran, Aruna; Aneja, Satinder; Chaturvedi, Mona K.; Sodhi, Jitender; Fitzwater, Sean Patrick; Chandra, Jagdish; Rath, Bimbadhar; Kainth, Udaypal S.; Saini, Savita; Black, Robert E; Santosham, Mathuram; Bhatnagar, Shinjini.

In: Journal of Tropical Pediatrics, Vol. 64, No. 2, 01.04.2018, p. 110-117.

Research output: Contribution to journalArticle

Bagri, NK, Bagri, N, Jana, M, Gupta, AK, Wadhwa, N, Lodha, R, Kabra, SK, Chandran, A, Aneja, S, Chaturvedi, MK, Sodhi, J, Fitzwater, SP, Chandra, J, Rath, B, Kainth, US, Saini, S, Black, RE, Santosham, M & Bhatnagar, S 2018, 'Efficacy of oral zinc supplementation in radiologically confirmed pneumonia: Secondary analysis of a randomized controlled trial', Journal of Tropical Pediatrics, vol. 64, no. 2, pp. 110-117. https://doi.org/10.1093/tropej/fmx036
Bagri, Narendra Kumar ; Bagri, Neha ; Jana, Manisha ; Gupta, Arun Kumar ; Wadhwa, Nitya ; Lodha, Rakesh ; Kabra, Sushil Kumar ; Chandran, Aruna ; Aneja, Satinder ; Chaturvedi, Mona K. ; Sodhi, Jitender ; Fitzwater, Sean Patrick ; Chandra, Jagdish ; Rath, Bimbadhar ; Kainth, Udaypal S. ; Saini, Savita ; Black, Robert E ; Santosham, Mathuram ; Bhatnagar, Shinjini. / Efficacy of oral zinc supplementation in radiologically confirmed pneumonia : Secondary analysis of a randomized controlled trial. In: Journal of Tropical Pediatrics. 2018 ; Vol. 64, No. 2. pp. 110-117.
@article{ed9c1bab7ee949e1b223703ced499aa8,
title = "Efficacy of oral zinc supplementation in radiologically confirmed pneumonia: Secondary analysis of a randomized controlled trial",
abstract = "Objective: To evaluate the effect of zinc as an adjuvant therapy in radiologically confirmed pneumonia in children 2-24 months of age. Patients and Methods: We analyzed data of 212 children with pneumonia for whom chest X-ray films were available at enrollment and at least two radiologists agreed on the diagnosis of pneumonia. We compared the time to recovery in the two groups (n=121, zinc group and n=91, placebo group) using a Cox proportional hazards regression model. Results: Time to recovery was similar in both groups [median interquartile range: zinc, 84 h (64, 140 h); placebo, 85 h (65, 140 h)]. The absolute risk reduction for treatment failure was 5.2{\%} (95{\%} confidence interval: -4.8, 15.1) with zinc supplementation. Conclusion: There was no significant beneficial effect of zinc on the duration of recovery or risk of treatment failure in children with radiologically confirmed pneumonia.",
keywords = "Chest X-ray, Children, Radiological pneumonia, Zinc",
author = "Bagri, {Narendra Kumar} and Neha Bagri and Manisha Jana and Gupta, {Arun Kumar} and Nitya Wadhwa and Rakesh Lodha and Kabra, {Sushil Kumar} and Aruna Chandran and Satinder Aneja and Chaturvedi, {Mona K.} and Jitender Sodhi and Fitzwater, {Sean Patrick} and Jagdish Chandra and Bimbadhar Rath and Kainth, {Udaypal S.} and Savita Saini and Black, {Robert E} and Mathuram Santosham and Shinjini Bhatnagar",
year = "2018",
month = "4",
day = "1",
doi = "10.1093/tropej/fmx036",
language = "English (US)",
volume = "64",
pages = "110--117",
journal = "Journal of Tropical Pediatrics",
issn = "0142-6338",
publisher = "Oxford University Press",
number = "2",

}

TY - JOUR

T1 - Efficacy of oral zinc supplementation in radiologically confirmed pneumonia

T2 - Secondary analysis of a randomized controlled trial

AU - Bagri, Narendra Kumar

AU - Bagri, Neha

AU - Jana, Manisha

AU - Gupta, Arun Kumar

AU - Wadhwa, Nitya

AU - Lodha, Rakesh

AU - Kabra, Sushil Kumar

AU - Chandran, Aruna

AU - Aneja, Satinder

AU - Chaturvedi, Mona K.

AU - Sodhi, Jitender

AU - Fitzwater, Sean Patrick

AU - Chandra, Jagdish

AU - Rath, Bimbadhar

AU - Kainth, Udaypal S.

AU - Saini, Savita

AU - Black, Robert E

AU - Santosham, Mathuram

AU - Bhatnagar, Shinjini

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Objective: To evaluate the effect of zinc as an adjuvant therapy in radiologically confirmed pneumonia in children 2-24 months of age. Patients and Methods: We analyzed data of 212 children with pneumonia for whom chest X-ray films were available at enrollment and at least two radiologists agreed on the diagnosis of pneumonia. We compared the time to recovery in the two groups (n=121, zinc group and n=91, placebo group) using a Cox proportional hazards regression model. Results: Time to recovery was similar in both groups [median interquartile range: zinc, 84 h (64, 140 h); placebo, 85 h (65, 140 h)]. The absolute risk reduction for treatment failure was 5.2% (95% confidence interval: -4.8, 15.1) with zinc supplementation. Conclusion: There was no significant beneficial effect of zinc on the duration of recovery or risk of treatment failure in children with radiologically confirmed pneumonia.

AB - Objective: To evaluate the effect of zinc as an adjuvant therapy in radiologically confirmed pneumonia in children 2-24 months of age. Patients and Methods: We analyzed data of 212 children with pneumonia for whom chest X-ray films were available at enrollment and at least two radiologists agreed on the diagnosis of pneumonia. We compared the time to recovery in the two groups (n=121, zinc group and n=91, placebo group) using a Cox proportional hazards regression model. Results: Time to recovery was similar in both groups [median interquartile range: zinc, 84 h (64, 140 h); placebo, 85 h (65, 140 h)]. The absolute risk reduction for treatment failure was 5.2% (95% confidence interval: -4.8, 15.1) with zinc supplementation. Conclusion: There was no significant beneficial effect of zinc on the duration of recovery or risk of treatment failure in children with radiologically confirmed pneumonia.

KW - Chest X-ray

KW - Children

KW - Radiological pneumonia

KW - Zinc

UR - http://www.scopus.com/inward/record.url?scp=85050638719&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85050638719&partnerID=8YFLogxK

U2 - 10.1093/tropej/fmx036

DO - 10.1093/tropej/fmx036

M3 - Article

C2 - 28575379

AN - SCOPUS:85050638719

VL - 64

SP - 110

EP - 117

JO - Journal of Tropical Pediatrics

JF - Journal of Tropical Pediatrics

SN - 0142-6338

IS - 2

ER -