Efficacy of Oral and Systemic Antibiotic Prophylaxis in Colorectal Operations

Robert E. Condon; John G. Bartlett; Herbert Greenlee; William J. Schulte; Shigeru Ochi; Robert Abbe; Joseph A. Caruana; H. Earl Gordon; J. Shelton Horsley; George Irvin; Willard Johnson; Paul Jordan; W. Ford Keitzer; Robert Lempke; Raymond C. Read; William Schumer; Michael Schwartz; F. Kristian Storm; R. Mark Vetto

doi:10.1001/archsurg.1983.01390040100021

Efficacy of Oral and Systemic Antibiotic Prophylaxis in Colorectal Operations

Robert E. Condon, John G. Bartlett, Herbert Greenlee, William J. Schulte, Shigeru Ochi, Robert Abbe, Joseph A. Caruana, H. Earl Gordon, J. Shelton Horsley, George Irvin, Willard Johnson, Paul Jordan, W. Ford Keitzer, Robert Lempke, Raymond C. Read, William Schumer, Michael Schwartz, F. Kristian Storm, R. Mark Vetto

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

A cooperative Veterans Administration study of the septic complication rate during large-bowel surgery was undertaken in two groups of patients. The first group received oral neomycin and erythromycin base plus parenteral placebo; the second, the oral antibiotics plus parenteral cephalothin sodium. During a five-year period, 1,128 patients were studied. The overall septic complication rate was 7.8% in patients receiving only oral antibiotics, and 5.7% in patients receiving both oral and parenteral antibiotics. This difference was not significant. The only significant finding was a greater incidence of fever of unknown origin in patients receiving only oral antibiotics. None of those patients were treated with additional antibiotics, and all fevers cleared spontaneously. There seems to be no discernible benefit from adding parenteral antibiotic prophylaxis when performing elective colon surgery if appropriate mechanical cleansing and oral neomycin and erthromycin therapy are employed.

Original language	English (US)
Pages (from-to)	496-502
Number of pages	7
Journal	Archives of surgery
Volume	118
Issue number	4
DOIs	https://doi.org/10.1001/archsurg.1983.01390040100021
State	Published - Apr 1983
Externally published	Yes

ASJC Scopus subject areas

Surgery

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10.1001/archsurg.1983.01390040100021

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Condon, R. E., Bartlett, J. G., Greenlee, H., Schulte, W. J., Ochi, S., Abbe, R., Caruana, J. A., Gordon, H. E., Horsley, J. S., Irvin, G., Johnson, W., Jordan, P., Keitzer, W. F., Lempke, R., Read, R. C., Schumer, W., Schwartz, M., Storm, F. K., & Vetto, R. M. (1983). Efficacy of Oral and Systemic Antibiotic Prophylaxis in Colorectal Operations. Archives of surgery, 118(4), 496-502. https://doi.org/10.1001/archsurg.1983.01390040100021

Condon, RE, Bartlett, JG, Greenlee, H, Schulte, WJ, Ochi, S, Abbe, R, Caruana, JA, Gordon, HE, Horsley, JS, Irvin, G, Johnson, W, Jordan, P, Keitzer, WF, Lempke, R, Read, RC, Schumer, W, Schwartz, M, Storm, FK & Vetto, RM 1983, 'Efficacy of Oral and Systemic Antibiotic Prophylaxis in Colorectal Operations', Archives of surgery, vol. 118, no. 4, pp. 496-502. https://doi.org/10.1001/archsurg.1983.01390040100021

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title = "Efficacy of Oral and Systemic Antibiotic Prophylaxis in Colorectal Operations",

abstract = "A cooperative Veterans Administration study of the septic complication rate during large-bowel surgery was undertaken in two groups of patients. The first group received oral neomycin and erythromycin base plus parenteral placebo; the second, the oral antibiotics plus parenteral cephalothin sodium. During a five-year period, 1,128 patients were studied. The overall septic complication rate was 7.8% in patients receiving only oral antibiotics, and 5.7% in patients receiving both oral and parenteral antibiotics. This difference was not significant. The only significant finding was a greater incidence of fever of unknown origin in patients receiving only oral antibiotics. None of those patients were treated with additional antibiotics, and all fevers cleared spontaneously. There seems to be no discernible benefit from adding parenteral antibiotic prophylaxis when performing elective colon surgery if appropriate mechanical cleansing and oral neomycin and erthromycin therapy are employed.",

author = "Condon, {Robert E.} and Bartlett, {John G.} and Herbert Greenlee and Schulte, {William J.} and Shigeru Ochi and Robert Abbe and Caruana, {Joseph A.} and Gordon, {H. Earl} and Horsley, {J. Shelton} and George Irvin and Willard Johnson and Paul Jordan and Keitzer, {W. Ford} and Robert Lempke and Read, {Raymond C.} and William Schumer and Michael Schwartz and Storm, {F. Kristian} and Vetto, {R. Mark}",

year = "1983",

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doi = "10.1001/archsurg.1983.01390040100021",

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AU - Abbe, Robert

AU - Caruana, Joseph A.

AU - Gordon, H. Earl

AU - Horsley, J. Shelton

AU - Irvin, George

AU - Johnson, Willard

AU - Jordan, Paul

AU - Keitzer, W. Ford

AU - Lempke, Robert

AU - Read, Raymond C.

AU - Schumer, William

AU - Schwartz, Michael

AU - Storm, F. Kristian

AU - Vetto, R. Mark

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AB - A cooperative Veterans Administration study of the septic complication rate during large-bowel surgery was undertaken in two groups of patients. The first group received oral neomycin and erythromycin base plus parenteral placebo; the second, the oral antibiotics plus parenteral cephalothin sodium. During a five-year period, 1,128 patients were studied. The overall septic complication rate was 7.8% in patients receiving only oral antibiotics, and 5.7% in patients receiving both oral and parenteral antibiotics. This difference was not significant. The only significant finding was a greater incidence of fever of unknown origin in patients receiving only oral antibiotics. None of those patients were treated with additional antibiotics, and all fevers cleared spontaneously. There seems to be no discernible benefit from adding parenteral antibiotic prophylaxis when performing elective colon surgery if appropriate mechanical cleansing and oral neomycin and erthromycin therapy are employed.

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Efficacy of Oral and Systemic Antibiotic Prophylaxis in Colorectal Operations

Abstract

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