Efficacy of mycobacterial components in the immunotherapy of mice with pulmonary tumor deposits

S. Sukumar, J. T. Hunter, E. Yarkoni, H. J. Rapp, B. Zbar, E. Lederer

Research output: Contribution to journalArticlepeer-review

Abstract

The effectiveness of each of two mycobacterial components and a synthetic analog of one of them in the eradication of pulmonary deposits of intravenously injected syngeneic fibrosarcoma 1023 in C3H mice was studied. BCG cell walls (BCG CW), trehalose 6,6′-dimycolate (TDM) or 6,6′-di-0-2-tetradecyl, 3-hydroxyoctadecanoyl-α,α-trehalose (C76), a synthetic analog of TDM, was administered in emulsified form by three different routes: intraperitoneal, intradermal, or intravenous, 24 h after intravenous injection of 1023 tumor cells. The most effective form of therapy was TDM given by the intraperitoneal route; about 50% of treated animals were cured. Higher doses of BCG CW or C76 also led to a significant number of cures. Each agent caused a significant prolongation of survival time of the treated mice at two or more of the dosages tested; however, their routes of optimal activity varied.

Original languageEnglish (US)
Pages (from-to)125-129
Number of pages5
JournalCancer Immunology Immunotherapy
Volume11
Issue number2
DOIs
StatePublished - Jun 1 1981
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology
  • Cancer Research

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