TY - JOUR
T1 - Efficacy of milk versus yogurt offered as part of a mixed diet in acute noncholera diarrhea among malnourished children
AU - Bhatnagar, S.
AU - Singh, K. D.
AU - Sazawal, S.
AU - Saxena, S. K.
AU - Bhan, M. K.
N1 - Funding Information:
Supported by the Diarrheal Diseases Control Programme, World Health Organization, Geneva, and the Indian Council of Medical Research.
PY - 1998
Y1 - 1998
N2 - We compared the clinical outcome of acute diarrhea in 96 malnourished boys (aged 4 to 47 months) receiving full-strength milk compared with yogurt offered as part of a mixed diet. All had weight for height less than or equal to 80% of the National Centre for Health Statistics median. They were randomly assigned to receive milk formula (MF; 67 cal/100 ml) or yogurt formula (YF; prepared from the same milk formula) at the rate of 120 ml/kg body weight in seven divided feedings. Stool-reducing substances (>1%) were detected more frequently in the MF group, and the differences were significant for day 3 of the study (p = 0.04). However, the geometric mean (95% confidence interval) of the total stool weight (gm/kg) during 0 to 72 hours (MF 128.8 [103, 161.4]; YF 110.9 [87, 142.2]) was comparable (p = 0.37), as was the median (range) duration of diarrhea (hours) (MF 45 [4, 183]; YF 52 [7, 173] p = 0.94). The treatment failure rates in the MF (8.2%) and YF (6.3%) groups were also similar (p = 0.67). The children consuming milk had higher median percent weight gain at the end of 72 hours of the study (p = 0.04) and at recovery (p = 0.02). Routine substitution of yogurt as small frequent feedings as an addition for semisolid food to malnourished children with acute diarrhea does not achieve any significant clinical benefit versus milk.
AB - We compared the clinical outcome of acute diarrhea in 96 malnourished boys (aged 4 to 47 months) receiving full-strength milk compared with yogurt offered as part of a mixed diet. All had weight for height less than or equal to 80% of the National Centre for Health Statistics median. They were randomly assigned to receive milk formula (MF; 67 cal/100 ml) or yogurt formula (YF; prepared from the same milk formula) at the rate of 120 ml/kg body weight in seven divided feedings. Stool-reducing substances (>1%) were detected more frequently in the MF group, and the differences were significant for day 3 of the study (p = 0.04). However, the geometric mean (95% confidence interval) of the total stool weight (gm/kg) during 0 to 72 hours (MF 128.8 [103, 161.4]; YF 110.9 [87, 142.2]) was comparable (p = 0.37), as was the median (range) duration of diarrhea (hours) (MF 45 [4, 183]; YF 52 [7, 173] p = 0.94). The treatment failure rates in the MF (8.2%) and YF (6.3%) groups were also similar (p = 0.67). The children consuming milk had higher median percent weight gain at the end of 72 hours of the study (p = 0.04) and at recovery (p = 0.02). Routine substitution of yogurt as small frequent feedings as an addition for semisolid food to malnourished children with acute diarrhea does not achieve any significant clinical benefit versus milk.
UR - http://www.scopus.com/inward/record.url?scp=0031814735&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031814735&partnerID=8YFLogxK
U2 - 10.1016/S0022-3476(98)70398-1
DO - 10.1016/S0022-3476(98)70398-1
M3 - Article
C2 - 9627593
AN - SCOPUS:0031814735
SN - 0022-3476
VL - 132
SP - 999
EP - 1003
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 6
ER -