Efficacy of meal replacements versus a standard food-based diet for weight loss in type 2 diabetes: a controlled clinical trial.

Lawrence J Cheskin, Amy M. Mitchell, Ami D. Jhaveri, Andrea H. Mitola, Lisa M. Davis, Rebecca A. Lewis, Mary A. Yep, Thomas W. Lycan

Research output: Contribution to journalArticle

Abstract

PURPOSE: The purpose of this study is to compare the efficacy of a portion-controlled meal replacement diet (PCD) to a standard diet (SD) based on recommendations by the American Diabetes Association in achieving and maintaining weight loss among obese participants with type 2 diabetes. METHODS: This study is a university-based, controlled clinical trial. Participants were 119 men and women with diabetes with a body mass index between 25 and 40 kg/m(2), assigned randomly to one of two 34-week, 75% of predicted energy need diets (portion controlled or standard, self-selected, food based) and then followed by 1-year maintenance. RESULTS: Using intention-to-treat analyses, weight loss at 34 weeks and weight maintenance at 86 weeks was significantly better on PCD versus SD. Approximately 40% of the PCD participants lost > or =5% of their initial weight compared with 12% of those on the SD. Significant improvements in biochemical and metabolic measures were observed at 34 weeks in both groups. The retention rate and self-reported ease of adherence in the PCD group were significantly higher throughout the study. CONCLUSIONS: A diet using portion-controlled meal replacements yielded significantly greater initial weight loss and less regain after 1 year of maintenance than a standard, self-selected, food-based diet. As PCDs may help obese patients with type 2 diabetes adhere to a weight control program, diabetes educators may consider recommending them as part of a comprehensive approach to weight control.

Original languageEnglish (US)
Pages (from-to)118-127
Number of pages10
JournalDiabetes Educator
Volume34
Issue number1
DOIs
StatePublished - Jan 2008

ASJC Scopus subject areas

  • Internal Medicine
  • Public Health, Environmental and Occupational Health
  • Endocrinology, Diabetes and Metabolism

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    Cheskin, L. J., Mitchell, A. M., Jhaveri, A. D., Mitola, A. H., Davis, L. M., Lewis, R. A., Yep, M. A., & Lycan, T. W. (2008). Efficacy of meal replacements versus a standard food-based diet for weight loss in type 2 diabetes: a controlled clinical trial. Diabetes Educator, 34(1), 118-127. https://doi.org/10.1177/0145721707312463