Efficacy of mass azithromycin distribution for reducing childhood mortality across geographic regions

MORDOR Study Group

Research output: Contribution to journalArticlepeer-review

Abstract

Mass azithromycin distribution has been shown to reduce all-cause mortality in preschool children in sub-Saharan Africa. However, substantial heterogeneity in the apparent effect has been noted across geographic settings, suggesting a greater relative benefit in higher mortality settings. Here, we evaluated the relationship between the underlying mortality rate and the efficacy of azithromycin for the prevention of child mortality using data from multiple sites in Ethiopia, Malawi, Niger, and Tanzania. Between regions, we find no strong evidence of effect modification of the efficacy of azithromycin distribution for the prevention of child mortality by the underlying mortality rate (P = 0.12), although a modest effect is consistent with our findings. Higher mortality settings could be prioritized, however, because of the larger number of deaths which could be averted with azithromycin distribution.

Original languageEnglish (US)
Pages (from-to)1291-1294
Number of pages4
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume103
Issue number3
DOIs
StatePublished - Sep 2020

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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