Efficacy of lasalocid against murine Pneumocystis carinii pneumonitis

H. S. Oz; W. T. Hughes; J. E. Rehg

doi:10.1128/aac.41.1.191

Efficacy of lasalocid against murine Pneumocystis carinii pneumonitis

H. S. Oz, W. T. Hughes, J. E. Rehg

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The efficacy of the ionophore lasalocid against Pneumocystis carinii pneumonitis in corticosteroid-immunosuppressed Sprague-Dawley rats was investigated. Lasalocid was effective in the prevention of the pneumonitis in a dose-dependent manner. At dosages of 0, 5, 10, and 20 mg/kg/day, P. carinii infection rates were 92, 60, 20, and 0%, respectively, during dexamethasone immunosuppression. Also, lasalocid compared favorably with other drugs known to have anti-P. carinii activity, including trimethoprim-sulfamethoxazole, atovaquone, and dapsone-trimethoprim.

Original language	English (US)
Pages (from-to)	191-192
Number of pages	2
Journal	Antimicrobial agents and chemotherapy
Volume	41
Issue number	1
DOIs	https://doi.org/10.1128/aac.41.1.191
State	Published - 1997
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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abstract = "The efficacy of the ionophore lasalocid against Pneumocystis carinii pneumonitis in corticosteroid-immunosuppressed Sprague-Dawley rats was investigated. Lasalocid was effective in the prevention of the pneumonitis in a dose-dependent manner. At dosages of 0, 5, 10, and 20 mg/kg/day, P. carinii infection rates were 92, 60, 20, and 0%, respectively, during dexamethasone immunosuppression. Also, lasalocid compared favorably with other drugs known to have anti-P. carinii activity, including trimethoprim-sulfamethoxazole, atovaquone, and dapsone-trimethoprim.",

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Efficacy of lasalocid against murine Pneumocystis carinii pneumonitis

Abstract

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