Efficacy of lasalocid against murine Pneumocystis carinii pneumonitis

H. S. Oz, W. T. Hughes, J. E. Rehg

Research output: Contribution to journalArticle

Abstract

The efficacy of the ionophore lasalocid against Pneumocystis carinii pneumonitis in corticosteroid-immunosuppressed Sprague-Dawley rats was investigated. Lasalocid was effective in the prevention of the pneumonitis in a dose-dependent manner. At dosages of 0, 5, 10, and 20 mg/kg/day, P. carinii infection rates were 92, 60, 20, and 0%, respectively, during dexamethasone immunosuppression. Also, lasalocid compared favorably with other drugs known to have anti-P. carinii activity, including trimethoprim-sulfamethoxazole, atovaquone, and dapsone-trimethoprim.

Original languageEnglish (US)
Pages (from-to)191-192
Number of pages2
JournalAntimicrobial agents and chemotherapy
Volume41
Issue number1
StatePublished - Jan 7 1997

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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