Efficacy of killed whole-parasite vaccines in the prevention of leishmaniasis-A meta-analysis

Sassan Noazin, Ali Khamesipour, Lawrence H. Moulton, Marcel Tanner, Kiumarss Nasseri, Farrokh Modabber, Iraj Sharifi, E. A.G. Khalil, Ivan Dario Velez Bernal, Carlos M.F. Antunes, Peter G. Smith

Research output: Contribution to journalReview article

Abstract

Despite decades of investigation in countries on three continents, an efficacious vaccine against Leishmania infections has not been developed. Although some indication of protection was observed in some of the controlled trials conducted with "first-generation" whole, inactivated Leishmania parasite vaccines, convincing evidence of protection was lacking. After reviewing all previously published or unpublished randomized, controlled field efficacy clinical trials of prophylactic candidate vaccines, a meta-analysis of qualified trials was conducted to evaluate whether there was some evidence of protection revealed by considering the results of all trials together. The findings indicate that the whole-parasite vaccine candidates tested do not confer significant protection against human leishmaniasis.

Original languageEnglish (US)
Pages (from-to)4747-4753
Number of pages7
JournalVaccine
Volume27
Issue number35
DOIs
StatePublished - Jul 30 2009

Keywords

  • Clinical trial
  • Leishmaniasis vaccine
  • Meta-analysis

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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  • Cite this

    Noazin, S., Khamesipour, A., Moulton, L. H., Tanner, M., Nasseri, K., Modabber, F., Sharifi, I., Khalil, E. A. G., Bernal, I. D. V., Antunes, C. M. F., & Smith, P. G. (2009). Efficacy of killed whole-parasite vaccines in the prevention of leishmaniasis-A meta-analysis. Vaccine, 27(35), 4747-4753. https://doi.org/10.1016/j.vaccine.2009.05.084