Efficacy of immune therapy in early experimental Naegleria fowleri meningitis

Gunther J. Lallinger, Steven L. Reiner, David W. Cooke, Dena L. Toffaletti, John R. Perfect, Donald L. Granger, David T. Durack

Research output: Contribution to journalArticlepeer-review

Abstract

Naegleria fowleri meningoencephalitis is usually fatal in humans despite treatment. As a new approach, we tested intracisternal passive immune therapy in rabbits with amebic meningoencephalitis by using antinaegleria immune serum, an immunoglobulin G fraction, and a newly developed monoclonal antibody to N. fowleri. Both the immune serum and an immunoglobulin G fraction isolated from it by affinity chromatography provided a consistent, although temporary, protective effect, shown by prolongation of survival (P = 0.001). Multiple doses of immune serum further prolonged survival (P = 0.005). The protective effect of serum was retained after heating to 56°C. We then developed a monoclonal antibody to N. fowleri which provided similar protection. Passive intracisternal antibody therapy might serve as an adjunctive component in the treatment of amebic meningoencephalitis.

Original languageEnglish (US)
Pages (from-to)1289-1293
Number of pages5
JournalInfection and immunity
Volume55
Issue number5
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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