Efficacy of fluoroquinolones against Leptospira interrogans in a hamster model

Matthew E. Griffith, James E. Moon, Erica N. Johnson, Kyra P. Clark, Joshua S. Hawley, Duane R. Hospenthal, Clinton K. Murray

Research output: Contribution to journalArticlepeer-review

Abstract

Ciprofloxacin, gatifloxacin, and levofloxacin were evaluated for their abilities to prevent mortality in hamsters infected with a lethal inoculum of Leptospira interrogans serovar Portlandvere. Each agent produced a statistically significant survival advantage compared to no treatment and demonstrated survival similar to that seen with doxycycline therapy.

Original languageEnglish (US)
Pages (from-to)2615-2617
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume51
Issue number7
DOIs
StatePublished - Jul 2007
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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