TY - JOUR
T1 - Efficacy of fecal microbiota transplantation in 2 children with recurrent Clostridium difficile infection and its impact on their growth and gut microbiome
AU - Walia, Ritu
AU - Garg, Shashank
AU - Song, Yang
AU - Girotra, Mohit
AU - Cuffari, Carmen
AU - Fricke, Wolfgang Florian
AU - Dutta, Sudhir K.
N1 - Publisher Copyright:
Copyright © 2014 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.
PY - 2014/11/8
Y1 - 2014/11/8
N2 - Fecal microbiota transplantation (FMT) is recognized as an alternative therapeutic modality for recurrent Clostridium difficile infection (RCDI); however, data on its efficacy in children are lacking, including its effect on their growth and fecal microbiota. We report on 2 young children (<3 years old) who failed available therapeutics for RCDI, but responded remarkably well to FMT. Besides resolution of clinical features of C difficile infection (CDI), FMT administration led to marked improvement in their growth, along with increased microbiota diversity, especially proportion of Bacteroides. Our 2 cases illustrate the efficacy of FMT in children with RCDI and its positive effect on their growth and gut microbiota.
AB - Fecal microbiota transplantation (FMT) is recognized as an alternative therapeutic modality for recurrent Clostridium difficile infection (RCDI); however, data on its efficacy in children are lacking, including its effect on their growth and fecal microbiota. We report on 2 young children (<3 years old) who failed available therapeutics for RCDI, but responded remarkably well to FMT. Besides resolution of clinical features of C difficile infection (CDI), FMT administration led to marked improvement in their growth, along with increased microbiota diversity, especially proportion of Bacteroides. Our 2 cases illustrate the efficacy of FMT in children with RCDI and its positive effect on their growth and gut microbiota.
KW - Clostridium difficile infection
KW - Fecal microbiota transplantation
KW - Growth
KW - Recurrent
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U2 - 10.1097/MPG.0000000000000495
DO - 10.1097/MPG.0000000000000495
M3 - Article
C2 - 25023578
AN - SCOPUS:84928287872
SN - 0277-2116
VL - 59
SP - 565
EP - 570
JO - Journal of pediatric gastroenterology and nutrition
JF - Journal of pediatric gastroenterology and nutrition
IS - 5
ER -