Efficacy of fecal microbiota transplantation in 2 children with recurrent Clostridium difficile infection and its impact on their growth and gut microbiome

Ritu Walia, Shashank Garg, Yang Song, Mohit Girotra, Carmen Cuffari, Wolfgang Florian Fricke, Sudhir K. Dutta

Research output: Contribution to journalArticle

Abstract

Fecal microbiota transplantation (FMT) is recognized as an alternative therapeutic modality for recurrent Clostridium difficile infection (RCDI); however, data on its efficacy in children are lacking, including its effect on their growth and fecal microbiota. We report on 2 young children (<3 years old) who failed available therapeutics for RCDI, but responded remarkably well to FMT. Besides resolution of clinical features of C difficile infection (CDI), FMT administration led to marked improvement in their growth, along with increased microbiota diversity, especially proportion of Bacteroides. Our 2 cases illustrate the efficacy of FMT in children with RCDI and its positive effect on their growth and gut microbiota.

Original languageEnglish (US)
Pages (from-to)565-570
Number of pages6
JournalJournal of pediatric gastroenterology and nutrition
Volume59
Issue number5
DOIs
StatePublished - Nov 8 2014

Keywords

  • Clostridium difficile infection
  • Fecal microbiota transplantation
  • Growth
  • Recurrent

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

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