Efficacy of coronary stenting versus balloon angioplasty in small coronary arteries

Michael P. Savage, David L. Fischman, Randal Rake, Martin B. Leon, Richard A. Schatz, Ian Penn, Masakiyo Nobuyoshi, Jeffrey Moses, John Hirshfeld, Richard Heuser, Donald Baim, Michael Cleman, Jeffrey Brinker, Sharon Gebhardt, Sheldon Goldberg

Research output: Contribution to journalArticle

Abstract

Objectives. The goal of this study was to compare the efficacy of elective stent implantation and balloon angioplasty for new lesions in small coronary arteries. Background. Palmaz-Schatz stents have been designed and approved by the Food and Drug Administration for use in coronary arteries with diameters ≤3.0 mm. The efficacy of elective stent placement in smaller vessels has not been determined. Methods. By quantitative coronary angiography, 331 patients in the Stent Restenosis Study (STRESS) I-II were determined to have a reference vessel <3.0 mm in diameter. Of these, 163 patients were randomly assigned to stenting (mean diameter 2.69 ± 0.21 ram), and 168 patients were assigned to angioplasty (mean diameter 2.64 ± 0.24 mm). The primary end point was restenosis, defined as ≤50% diameter stenosis at 6-month follow-up angiography. Clinical event rates at 1 year were assessed. Resters. Baseline clinical and angiographic characteristics were similar in the two groups. Procedural success was achieved in 1000 of patients assigned to stenting and in 92% of patients assigned to angioplasty (p < 0.001). Abrupt closure within 30 days occurred in 3.6% of patients in both groups. Compared with angioplasty, stenting conferred a significantly larger postprocedural lumen diameter (2.26 vs. 1.80 nun, p < 0.001) and a larger lumen at 6 months (1.54 vs. 1.27 mm, p < 0.001). Restenosis (≤50% diameter stenosis at follow-up) occurred in 34% of patients assigned to stenting and in 55% of patients assigned to angioplasty (p < 0.001). At 1 year, event-free survival was achieved in 78% of the stent group and in 67% of the angioplasty group (p = 0.019). Conclusions. These findings suggest that elective stent placement provides superior angiographic and clinical outcomes than balloon angioplasty in vessels slightly smaller than 3 min.

Original languageEnglish (US)
Pages (from-to)307-311
Number of pages5
JournalJournal of the American College of Cardiology
Volume31
Issue number2
DOIs
StatePublished - Feb 1 1998

    Fingerprint

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Savage, M. P., Fischman, D. L., Rake, R., Leon, M. B., Schatz, R. A., Penn, I., Nobuyoshi, M., Moses, J., Hirshfeld, J., Heuser, R., Baim, D., Cleman, M., Brinker, J., Gebhardt, S., & Goldberg, S. (1998). Efficacy of coronary stenting versus balloon angioplasty in small coronary arteries. Journal of the American College of Cardiology, 31(2), 307-311. https://doi.org/10.1016/S0735-1097(97)00511-1