Efficacy of conventional cytogenetics and FISH for EGR1 to detect deletion 5q in hematological disorders and to assess response to treatment with Lenalidomide

Ying S. Zou; Stephanie R. Fink; Kimberly J. Stockero; Sarah F. Paternoster; Stephanie A. Smoley; Han W. Tun; Craig B. Reeder; Ayalew Tefferi; Gordon W. Dewald

doi:10.1016/j.leukres.2006.10.011

Efficacy of conventional cytogenetics and FISH for EGR1 to detect deletion 5q in hematological disorders and to assess response to treatment with Lenalidomide

Ying S. Zou, Stephanie R. Fink, Kimberly J. Stockero, Sarah F. Paternoster, Stephanie A. Smoley, Han W. Tun, Craig B. Reeder, Ayalew Tefferi, Gordon W. Dewald

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

In clinical practice, whether FISH for EGR1 in interphase nuclei has similar efficacy to detect deletion 5q anomalies as conventional cytogenetic studies is unknown. We compared conventional cytogenetics and FISH for 145 patients with deletion 5q and detected this anomaly by both methods in 144. Nine patients with myelodysplasia were studied before and after treatment with Lenalidomide and results were concordant for 28 of 29 specimens. FISH did not detect anomalies other than deletion 5q in 31 patients. This study suggests FISH is useful to detect deletion 5q, but is not a substitute for conventional cytogenetics.

Original language	English (US)
Pages (from-to)	1185-1189
Number of pages	5
Journal	Leukemia Research
Volume	31
Issue number	9
DOIs	https://doi.org/10.1016/j.leukres.2006.10.011
State	Published - Sep 2007
Externally published	Yes

Keywords

Acute leukemia
Deletion 5q
EGR1
Myelodysplasia

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/j.leukres.2006.10.011

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Zou, Y. S., Fink, S. R., Stockero, K. J., Paternoster, S. F., Smoley, S. A., Tun, H. W., Reeder, C. B., Tefferi, A., & Dewald, G. W. (2007). Efficacy of conventional cytogenetics and FISH for EGR1 to detect deletion 5q in hematological disorders and to assess response to treatment with Lenalidomide. Leukemia Research, 31(9), 1185-1189. https://doi.org/10.1016/j.leukres.2006.10.011

Zou, YS, Fink, SR, Stockero, KJ, Paternoster, SF, Smoley, SA, Tun, HW, Reeder, CB, Tefferi, A & Dewald, GW 2007, 'Efficacy of conventional cytogenetics and FISH for EGR1 to detect deletion 5q in hematological disorders and to assess response to treatment with Lenalidomide', Leukemia Research, vol. 31, no. 9, pp. 1185-1189. https://doi.org/10.1016/j.leukres.2006.10.011

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title = "Efficacy of conventional cytogenetics and FISH for EGR1 to detect deletion 5q in hematological disorders and to assess response to treatment with Lenalidomide",

abstract = "In clinical practice, whether FISH for EGR1 in interphase nuclei has similar efficacy to detect deletion 5q anomalies as conventional cytogenetic studies is unknown. We compared conventional cytogenetics and FISH for 145 patients with deletion 5q and detected this anomaly by both methods in 144. Nine patients with myelodysplasia were studied before and after treatment with Lenalidomide and results were concordant for 28 of 29 specimens. FISH did not detect anomalies other than deletion 5q in 31 patients. This study suggests FISH is useful to detect deletion 5q, but is not a substitute for conventional cytogenetics.",

keywords = "Acute leukemia, Deletion 5q, EGR1, Myelodysplasia",

author = "Zou, {Ying S.} and Fink, {Stephanie R.} and Stockero, {Kimberly J.} and Paternoster, {Sarah F.} and Smoley, {Stephanie A.} and Tun, {Han W.} and Reeder, {Craig B.} and Ayalew Tefferi and Dewald, {Gordon W.}",

year = "2007",

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doi = "10.1016/j.leukres.2006.10.011",

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AU - Zou, Ying S.

AU - Fink, Stephanie R.

AU - Stockero, Kimberly J.

AU - Paternoster, Sarah F.

AU - Smoley, Stephanie A.

AU - Tun, Han W.

AU - Reeder, Craig B.

AU - Tefferi, Ayalew

AU - Dewald, Gordon W.

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AB - In clinical practice, whether FISH for EGR1 in interphase nuclei has similar efficacy to detect deletion 5q anomalies as conventional cytogenetic studies is unknown. We compared conventional cytogenetics and FISH for 145 patients with deletion 5q and detected this anomaly by both methods in 144. Nine patients with myelodysplasia were studied before and after treatment with Lenalidomide and results were concordant for 28 of 29 specimens. FISH did not detect anomalies other than deletion 5q in 31 patients. This study suggests FISH is useful to detect deletion 5q, but is not a substitute for conventional cytogenetics.

KW - Acute leukemia

KW - Deletion 5q

KW - EGR1

KW - Myelodysplasia

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Efficacy of conventional cytogenetics and FISH for EGR1 to detect deletion 5q in hematological disorders and to assess response to treatment with Lenalidomide

Abstract

Keywords

ASJC Scopus subject areas

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