Efficacy of combined jejunal and colonic fecal microbiota transplantation for recurrent clostridium difficile infection

Sudhir K. Dutta, Mohit Girotra, Shashank Garg, Anand Dutta, Erik C. von Rosenvinge, Cynthia Maddox, Yang Song, John Bartlett, Rakesh Vinayek, W. Florian Fricke

Research output: Contribution to journalArticle

Abstract

The prevalence of recurrent Clostridium difficile infection (RCDI) is increasing; fecal microbiota transplantation (FMT) is an effective therapy. However, there have been no studies of the efficacy of a single session of combined enteral and colonic FMT or characterizations of changes in the microbiota between donors and recipients. We performed a study of 27 patients with RCDI who were given a fixed volume of processed fecal filtrate via enteroscopy and colonoscopy in a single session. Patients were closely monitored, and fecal samples were collected from 2 patient-donor pairs for 16S rRNA analysis. All patients had reduced stool frequency, abdominal pain, white blood cell counts, and elimination of fecal C difficile toxin (P

Original languageEnglish (US)
Pages (from-to)1572-1576
Number of pages5
JournalClinical Gastroenterology and Hepatology
Volume12
Issue number9
DOIs
StatePublished - 2014

Fingerprint

Clostridium Infections
Clostridium difficile
Tissue Donors
Microbiota
Colonoscopy
Leukocyte Count
Abdominal Pain
Small Intestine
Fecal Microbiota Transplantation

Keywords

  • 16s rrna analysis
  • Clostridium difficile
  • Colonic
  • Fecal microbiota transplantation
  • FMT
  • Jejunal
  • Lachnospiraceae
  • Microbiota
  • RCDI
  • Recurrent

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology
  • Medicine(all)

Cite this

Efficacy of combined jejunal and colonic fecal microbiota transplantation for recurrent clostridium difficile infection. / Dutta, Sudhir K.; Girotra, Mohit; Garg, Shashank; Dutta, Anand; von Rosenvinge, Erik C.; Maddox, Cynthia; Song, Yang; Bartlett, John; Vinayek, Rakesh; Fricke, W. Florian.

In: Clinical Gastroenterology and Hepatology, Vol. 12, No. 9, 2014, p. 1572-1576.

Research output: Contribution to journalArticle

Dutta, SK, Girotra, M, Garg, S, Dutta, A, von Rosenvinge, EC, Maddox, C, Song, Y, Bartlett, J, Vinayek, R & Fricke, WF 2014, 'Efficacy of combined jejunal and colonic fecal microbiota transplantation for recurrent clostridium difficile infection', Clinical Gastroenterology and Hepatology, vol. 12, no. 9, pp. 1572-1576. https://doi.org/10.1016/j.cgh.2013.12.032
Dutta, Sudhir K. ; Girotra, Mohit ; Garg, Shashank ; Dutta, Anand ; von Rosenvinge, Erik C. ; Maddox, Cynthia ; Song, Yang ; Bartlett, John ; Vinayek, Rakesh ; Fricke, W. Florian. / Efficacy of combined jejunal and colonic fecal microbiota transplantation for recurrent clostridium difficile infection. In: Clinical Gastroenterology and Hepatology. 2014 ; Vol. 12, No. 9. pp. 1572-1576.
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