Efficacy of combined jejunal and colonic fecal microbiota transplantation for recurrent clostridium difficile infection

Sudhir K. Dutta, Mohit Girotra, Shashank Garg, Anand Dutta, Erik C. von Rosenvinge, Cynthia Maddox, Yang Song, John Bartlett, Rakesh Vinayek, W. Florian Fricke

Research output: Contribution to journalArticle

Abstract

The prevalence of recurrent Clostridium difficile infection (RCDI) is increasing; fecal microbiota transplantation (FMT) is an effective therapy. However, there have been no studies of the efficacy of a single session of combined enteral and colonic FMT or characterizations of changes in the microbiota between donors and recipients. We performed a study of 27 patients with RCDI who were given a fixed volume of processed fecal filtrate via enteroscopy and colonoscopy in a single session. Patients were closely monitored, and fecal samples were collected from 2 patient-donor pairs for 16S rRNA analysis. All patients had reduced stool frequency, abdominal pain, white blood cell counts, and elimination of fecal C difficile toxin (P

Original languageEnglish (US)
Pages (from-to)1572-1576
Number of pages5
JournalClinical Gastroenterology and Hepatology
Volume12
Issue number9
DOIs
Publication statusPublished - 2014

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Keywords

  • 16s rrna analysis
  • Clostridium difficile
  • Colonic
  • Fecal microbiota transplantation
  • FMT
  • Jejunal
  • Lachnospiraceae
  • Microbiota
  • RCDI
  • Recurrent

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology
  • Medicine(all)

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