Efficacy of chloroquine in the treatment of uncomplicated, Plasmodium falciparum malaria in northern Ghana

Stephan Ehrhardt, F. P. Mockenhaupt, P. Agana-Nsiire, A. Mathieu, S. D. Anemana, K. Stark, R. N. Otchwemah, U. Bienzle

Research output: Contribution to journalArticle

Abstract

Chloroquine (CQ) resistance in Plasmodium falciparum contributes to growing malaria-attributable morbidity and mortality in sub-Saharan Africa. However, the extent and degree of such resistance vary considerably between endemic areas. Data on CQ resistance in northern Ghana are almost entirely lacking. The therapeutic efficacy of CQ in uncomplicated malaria was therefore assessed, in a standard, 14-day protocol, in 225 children aged 25% of the children and more than half of the parasitological responses indicated resistance, current recommendations for the treatment of uncomplicated malaria in young children in northern Ghana have to be reconsidered.

Original languageEnglish (US)
Pages (from-to)239-247
Number of pages9
JournalAnnals of Tropical Medicine and Parasitology
Volume96
Issue number3
DOIs
StatePublished - 2002
Externally publishedYes

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Ghana
Falciparum Malaria
Chloroquine
Malaria
Africa South of the Sahara
Plasmodium falciparum
Therapeutics
Morbidity
Mortality

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Immunology

Cite this

Efficacy of chloroquine in the treatment of uncomplicated, Plasmodium falciparum malaria in northern Ghana. / Ehrhardt, Stephan; Mockenhaupt, F. P.; Agana-Nsiire, P.; Mathieu, A.; Anemana, S. D.; Stark, K.; Otchwemah, R. N.; Bienzle, U.

In: Annals of Tropical Medicine and Parasitology, Vol. 96, No. 3, 2002, p. 239-247.

Research output: Contribution to journalArticle

Ehrhardt, S, Mockenhaupt, FP, Agana-Nsiire, P, Mathieu, A, Anemana, SD, Stark, K, Otchwemah, RN & Bienzle, U 2002, 'Efficacy of chloroquine in the treatment of uncomplicated, Plasmodium falciparum malaria in northern Ghana', Annals of Tropical Medicine and Parasitology, vol. 96, no. 3, pp. 239-247. https://doi.org/10.1179/000349802125000772
Ehrhardt, Stephan ; Mockenhaupt, F. P. ; Agana-Nsiire, P. ; Mathieu, A. ; Anemana, S. D. ; Stark, K. ; Otchwemah, R. N. ; Bienzle, U. / Efficacy of chloroquine in the treatment of uncomplicated, Plasmodium falciparum malaria in northern Ghana. In: Annals of Tropical Medicine and Parasitology. 2002 ; Vol. 96, No. 3. pp. 239-247.
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