Efficacy of cefotaxime and latamoxef for Escherichia Coli bacteremia and meningitis in newborn rats

Kwang Sik Kim, Marian Manocchio, Arnold S. Bayer

Research output: Contribution to journalArticle

Abstract

We have evaluated the efficacy of cefotaxime and latamoxef against a Kl Escherichia coli strain in vitro and in vivo. In vitro, the minimal inhibitory concentrations (MICs) were close to the minimal bactericidal concentrations (MBCs) for both antibiotics (≤ 2 dilutions). However, with an inoculum of 107 CFU/ml, MIC and MBC were significantly greater than those with inocula of 103 and 105. In vivo study with an infant rat model of bacteremia and meningitis revealed that (I) both cefotaxime and latamoxef penetrated well into the cerebrospinal fluid (CSF), (2) both drugs were bactericidal in blood and CSF, (3) both were effective in prevention of the development of meningitis in bacteremic animals, and (4) the mortality rates were significantly less in the treated than in the control group (p <0.001). However, even with cefotaxime or latamoxef treatment, the mortality was significantly greater (p<0.001) in rats whose bacterial counts before therapy were > 106 CFU/ml of blood. These findings suggest that the effects of cefotaxime and latamoxef may be directly correlated with the size of the bacterial population exposed to these agents and that this variable may be an important factor to influence the therapeutic outcome.

Original languageEnglish (US)
Pages (from-to)262-269
Number of pages8
JournalChemotherapy
Volume30
Issue number4
DOIs
StatePublished - 1984
Externally publishedYes

Fingerprint

Escherichia coli Meningitis
Moxalactam
Cefotaxime
Bacteremia
Meningitis
Cerebrospinal Fluid
Population Density
Escherichia coli
Anti-Bacterial Agents
Control Groups
Mortality
Pharmaceutical Preparations
In Vitro Techniques
Therapeutics

Keywords

  • Cefotaxime
  • Escherichia coll
  • In vitro/in vivo studies
  • Latamoxef

ASJC Scopus subject areas

  • Infectious Diseases
  • Oncology
  • Pharmacology (medical)
  • Drug Discovery
  • Pharmacology

Cite this

Efficacy of cefotaxime and latamoxef for Escherichia Coli bacteremia and meningitis in newborn rats. / Kim, Kwang Sik; Manocchio, Marian; Bayer, Arnold S.

In: Chemotherapy, Vol. 30, No. 4, 1984, p. 262-269.

Research output: Contribution to journalArticle

Kim, Kwang Sik ; Manocchio, Marian ; Bayer, Arnold S. / Efficacy of cefotaxime and latamoxef for Escherichia Coli bacteremia and meningitis in newborn rats. In: Chemotherapy. 1984 ; Vol. 30, No. 4. pp. 262-269.
@article{da064944da9842a5b354e5e9895b9887,
title = "Efficacy of cefotaxime and latamoxef for Escherichia Coli bacteremia and meningitis in newborn rats",
abstract = "We have evaluated the efficacy of cefotaxime and latamoxef against a Kl Escherichia coli strain in vitro and in vivo. In vitro, the minimal inhibitory concentrations (MICs) were close to the minimal bactericidal concentrations (MBCs) for both antibiotics (≤ 2 dilutions). However, with an inoculum of 107 CFU/ml, MIC and MBC were significantly greater than those with inocula of 103 and 105. In vivo study with an infant rat model of bacteremia and meningitis revealed that (I) both cefotaxime and latamoxef penetrated well into the cerebrospinal fluid (CSF), (2) both drugs were bactericidal in blood and CSF, (3) both were effective in prevention of the development of meningitis in bacteremic animals, and (4) the mortality rates were significantly less in the treated than in the control group (p <0.001). However, even with cefotaxime or latamoxef treatment, the mortality was significantly greater (p<0.001) in rats whose bacterial counts before therapy were > 106 CFU/ml of blood. These findings suggest that the effects of cefotaxime and latamoxef may be directly correlated with the size of the bacterial population exposed to these agents and that this variable may be an important factor to influence the therapeutic outcome.",
keywords = "Cefotaxime, Escherichia coll, In vitro/in vivo studies, Latamoxef",
author = "Kim, {Kwang Sik} and Marian Manocchio and Bayer, {Arnold S.}",
year = "1984",
doi = "10.1159/000238278",
language = "English (US)",
volume = "30",
pages = "262--269",
journal = "Chemotherapy",
issn = "0009-3157",
publisher = "S. Karger AG",
number = "4",

}

TY - JOUR

T1 - Efficacy of cefotaxime and latamoxef for Escherichia Coli bacteremia and meningitis in newborn rats

AU - Kim, Kwang Sik

AU - Manocchio, Marian

AU - Bayer, Arnold S.

PY - 1984

Y1 - 1984

N2 - We have evaluated the efficacy of cefotaxime and latamoxef against a Kl Escherichia coli strain in vitro and in vivo. In vitro, the minimal inhibitory concentrations (MICs) were close to the minimal bactericidal concentrations (MBCs) for both antibiotics (≤ 2 dilutions). However, with an inoculum of 107 CFU/ml, MIC and MBC were significantly greater than those with inocula of 103 and 105. In vivo study with an infant rat model of bacteremia and meningitis revealed that (I) both cefotaxime and latamoxef penetrated well into the cerebrospinal fluid (CSF), (2) both drugs were bactericidal in blood and CSF, (3) both were effective in prevention of the development of meningitis in bacteremic animals, and (4) the mortality rates were significantly less in the treated than in the control group (p <0.001). However, even with cefotaxime or latamoxef treatment, the mortality was significantly greater (p<0.001) in rats whose bacterial counts before therapy were > 106 CFU/ml of blood. These findings suggest that the effects of cefotaxime and latamoxef may be directly correlated with the size of the bacterial population exposed to these agents and that this variable may be an important factor to influence the therapeutic outcome.

AB - We have evaluated the efficacy of cefotaxime and latamoxef against a Kl Escherichia coli strain in vitro and in vivo. In vitro, the minimal inhibitory concentrations (MICs) were close to the minimal bactericidal concentrations (MBCs) for both antibiotics (≤ 2 dilutions). However, with an inoculum of 107 CFU/ml, MIC and MBC were significantly greater than those with inocula of 103 and 105. In vivo study with an infant rat model of bacteremia and meningitis revealed that (I) both cefotaxime and latamoxef penetrated well into the cerebrospinal fluid (CSF), (2) both drugs were bactericidal in blood and CSF, (3) both were effective in prevention of the development of meningitis in bacteremic animals, and (4) the mortality rates were significantly less in the treated than in the control group (p <0.001). However, even with cefotaxime or latamoxef treatment, the mortality was significantly greater (p<0.001) in rats whose bacterial counts before therapy were > 106 CFU/ml of blood. These findings suggest that the effects of cefotaxime and latamoxef may be directly correlated with the size of the bacterial population exposed to these agents and that this variable may be an important factor to influence the therapeutic outcome.

KW - Cefotaxime

KW - Escherichia coll

KW - In vitro/in vivo studies

KW - Latamoxef

UR - http://www.scopus.com/inward/record.url?scp=0021682824&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021682824&partnerID=8YFLogxK

U2 - 10.1159/000238278

DO - 10.1159/000238278

M3 - Article

C2 - 6086247

AN - SCOPUS:0021682824

VL - 30

SP - 262

EP - 269

JO - Chemotherapy

JF - Chemotherapy

SN - 0009-3157

IS - 4

ER -