Efficacy of carteolol hydrochloride 1% vs timolol maleate 0.5% in patients with increased intraocular pressure

W. C. Stewart, J. S. Cohen, P. A. Netland, H. Weiss, L. L. Nussbaum, D. Abrams, G. Schwartz, P. Hughes, A. Adelson, M. Brink, M. Myers, R. Bahr, Jr Dowling, F. Richards, A. Geltzer, R. J. Hofmann, L. Snady-McCoy, L. A. Bartnik, J. Beneke, L. BarrD. Muroski, J. Neal, C. Clevenger, B. Summitt, A. Lee, J. Cohen, K. A. Riccio, A. Luechauer, H. DuBiner, S. Cribbs, R. Laibovitz, K. Neck, T. Mundorf, D. Otero, P. A. Netland, D. A. Vivolo, L. Schwartz, P. Carmichael, R. Conner, T. Nowinski, J. Keselring, A. Bollenbach, A. Foley, W. Stewart, J. Stewart, C. Chase, H. Weiss, A. Schwartz, B. D. Latham

Research output: Contribution to journalArticle

Abstract

PURPOSE: To evaluate the ocular hypotensive effect and safety of carteolol hydrochloride 1% vs timolol maleate 0.5%. METHODS: One hundred seventy-six patients with ocular hypertension or primary open-angle glaucoma were randomly assigned to receive either carteolol 1% twice a day or timolol maleate 0.5% solution twice a day in a randomized, double-masked, multicenter, parallel-group, active-control comparison trial during a 3- month period. RESULTS: After 12 weeks, carteolol 1% reduced the mean ± SE intraocular pressure from 25.0 ± 0.3 to 19.5 ± 0.3 mm Hg; timolol maleate 0.5% reduced the mean intraocular pressure from 25.2 ± 0.3 to 19.6 ± 0.3 mm Hg. The mean difference in trough intraocular pressure between carteolol and timolol maleate of -0.14 mm Hg was not significantly (P = .745) different (95% confidence limits, -0.97 to 0.70 mm Hg). Trough pulse and blood pressure also showed no consistent statistically significant differences between groups. The 2-hour post-dose pulse, however, demonstrated a greater decrease in the timolol maleate than in the carteolol group (P < .001). Systemic and ocular signs and symptoms were similar between the groups except that the number of treatment-emergent reports of bradycardia was greater in the timolol maleate group (P = .039), and the carteolol group reported fewer ocular symptoms than the timolol maleate group did (P < .01). CONCLUSIONS: Both carteolol 1% and timolol maleate 0.5% are highly effective in lowering intraocular pressure when measured at the end of the dosing interval. Carteolol 1% demonstrates an ocular hypotensive effect and safety profile similar to those of timolol maleate 0.5% solution.

Original languageEnglish (US)
Pages (from-to)498-505
Number of pages8
JournalAmerican journal of ophthalmology
Volume124
Issue number4
DOIs
StatePublished - Jan 1 1997

ASJC Scopus subject areas

  • Ophthalmology

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    Stewart, W. C., Cohen, J. S., Netland, P. A., Weiss, H., Nussbaum, L. L., Abrams, D., Schwartz, G., Hughes, P., Adelson, A., Brink, M., Myers, M., Bahr, R., Dowling, J., Richards, F., Geltzer, A., Hofmann, R. J., Snady-McCoy, L., Bartnik, L. A., Beneke, J., ... Latham, B. D. (1997). Efficacy of carteolol hydrochloride 1% vs timolol maleate 0.5% in patients with increased intraocular pressure. American journal of ophthalmology, 124(4), 498-505. https://doi.org/10.1016/S0002-9394(14)70865-7