Efficacy of antiseptic-impregnated central venous catheters in preventing catheter-related bloodstream infection: A meta-analysis

David L. Veenstra, Sanjay Saint, Somnath Saha, Thomas Lumley, Sean D. Sullivan

Research output: Contribution to journalArticlepeer-review

479 Scopus citations

Abstract

Context. Central venous catheters impregnated with chlorhexidine and silver sulfadiazine have recently been introduced for the prevention of catheter-related infections. However, there remains some uncertainly regarding the efficacy of these catheters because of conflicting reports in the literature. Objective. To evaluate the efficacy of chlorhexidine-silver sulfadiazine-impregnated central venous catheters in the prevention of catheter-related bloodstream infection. Data Sources. Studies identified from a computerized search of the MEDLINE database from January 1966 to January 1998, reference lists of identified articles, and queries of principal investigators and the catheter manufacturer. Study Selection. Randomized trials comparing chlorhexidine-silver sulfadiazine-impregnated central venous catheters with nonimpregnated catheters were included. The outcomes assessed were catheter colonization and catheter-related bloodstream infection confirmed by catheter culture. Data Extraction. Twelve studies met the inclusion criteria for catheter colonization and included a total of 2611 catheters. Eleven studies with a total of 2603 catheters met the inclusion criteria for catheter-related bloodstream infection. Most patients in these studies were from groups considered to be at high risk for catheter-related infections. Summary statistics were calculated using Mantel-Haenszel methods under a fixed-effects model. Data Synthesis. The summary odds ratio for catheter colonization was 0.44 (95% confidence interval [CI], 0.36-0.54; P

Original languageEnglish (US)
Pages (from-to)261-267
Number of pages7
JournalJournal of the American Medical Association
Volume281
Issue number3
DOIs
StatePublished - Jan 20 1999
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine

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