Abstract
Surgical site infections (SSIs) are commonly caused by Staphylococcus aureus. We report that a combination of three monoclonal antibodies (MEDI6389) that neutralize S. aureus alpha-toxin, clumping factor A, and four leukocidins (LukSF, LukED, HlgAB, and HlgCB) plus vancomycin had enhanced efficacy compared with control antibody plus vancomycin in two mouse models of S. aureus SSI. Therefore, monoclonal antibody-based neutralization of multiple S. aureus virulence factors may provide an adjunctive perioperative approach to combat S. aureus SSIs.
Original language | English (US) |
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Article number | e00346-19 |
Journal | Antimicrobial agents and chemotherapy |
Volume | 63 |
Issue number | 8 |
DOIs | |
State | Published - Jan 1 2019 |
Keywords
- Alpha-toxin
- ClfA
- Clumping factor A
- HLA
- Leukocidin
- MRSA
- Staphylococcus aureus
- Surgical
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases