@article{9117a55290d24c2081fe1d3a693032e8,
title = "Efficacy of a multimechanistic monoclonal antibody combination against staphylococcus aureus surgical site infections in mice",
abstract = "Surgical site infections (SSIs) are commonly caused by Staphylococcus aureus. We report that a combination of three monoclonal antibodies (MEDI6389) that neutralize S. aureus alpha-toxin, clumping factor A, and four leukocidins (LukSF, LukED, HlgAB, and HlgCB) plus vancomycin had enhanced efficacy compared with control antibody plus vancomycin in two mouse models of S. aureus SSI. Therefore, monoclonal antibody-based neutralization of multiple S. aureus virulence factors may provide an adjunctive perioperative approach to combat S. aureus SSIs.",
keywords = "Alpha-toxin, ClfA, Clumping factor A, HLA, Leukocidin, MRSA, Staphylococcus aureus, Surgical",
author = "Ortines, {Roger V.} and Yu Wang and Haiyun Liu and Dikeman, {Dustin A.} and Pinsker, {Bret L.} and Miller, {Robert J.} and Kim, {Sophia E.} and Ackerman, {Nicole E.} and Rizkallah, {Joe F.} and Marcello, {Lee Ann T.} and Cohen, {Taylor S.} and Christine Tkaczyk and Sellman, {Bret R.} and Miller, {Lloyd S.}",
note = "Funding Information: This work was supported by a sponsored research agreement from AstraZeneca through a Johns Hopkins-MedImmune Academic Industry Partnership. Funding Information: L.S.M. has received grant support from AstraZeneca for the work reported in the manuscript and other grant support from Pfizer, Boehringer Ingelheim, Regeneron Pharmaceuticals, and Moderna Therapeutics. L.S.M. is also a shareholder of Noveome Biotherapeutics and is on the scientific advisory board of Integrated Biotherapeutics. These companies are developing therapeutics and vaccines against S. aureus and other pathogens. L.S.M. is also supported by grants from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR069502 and R01AR073665) from the U.S. National Institutes of Health. T.S.C., C.T., and B.R.S. are employed by AstraZeneca and may hold AstraZeneca stock. Publisher Copyright: Copyright {\textcopyright} 2019 American Society for Microbiology. All Rights Reserved.",
year = "2019",
doi = "10.1128/AAC.00346-19",
language = "English (US)",
volume = "63",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "8",
}