Efficacy of a Multimechanistic Monoclonal Antibody Combination against Staphylococcus aureus Surgical Site Infections in Mice

Roger V. Ortines, Yu Wang, Haiyun Liu, Dustin A. Dikeman, Bret L. Pinsker, Robert J. Miller, Sophia E. Kim, Nicole E. Ackerman, Joe F. Rizkallah, Lee Ann T. Marcello, Taylor S. Cohen, Christine Tkaczyk, Bret R. Sellman, Lloyd S Miller

Research output: Contribution to journalArticle

Abstract

Surgical site infections (SSIs) are commonly caused by Staphylococcus aureus We report that a combination of three monoclonal antibodies (MEDI6389) that neutralize S. aureus alpha-toxin, clumping factor A, and four leukocidins (LukSF, LukED, HlgAB, and HlgCB) plus vancomycin had enhanced efficacy compared with control antibody plus vancomycin in two mouse models of S. aureus SSI. Therefore, monoclonal antibody-based neutralization of multiple S. aureus virulence factors may provide an adjunctive perioperative approach to combat S. aureus SSIs.

Original languageEnglish (US)
JournalAntimicrobial agents and chemotherapy
Volume63
Issue number8
DOIs
StatePublished - Aug 1 2019

Fingerprint

Surgical Wound Infection
Staphylococcus aureus
Monoclonal Antibodies
Vancomycin
Leukocidins
Virulence Factors
Antibodies

Keywords

  • alpha-toxin
  • ClfA
  • clumping factor A
  • hla
  • leukocidin
  • MRSA
  • Staphylococcus aureus
  • surgical

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Efficacy of a Multimechanistic Monoclonal Antibody Combination against Staphylococcus aureus Surgical Site Infections in Mice. / Ortines, Roger V.; Wang, Yu; Liu, Haiyun; Dikeman, Dustin A.; Pinsker, Bret L.; Miller, Robert J.; Kim, Sophia E.; Ackerman, Nicole E.; Rizkallah, Joe F.; Marcello, Lee Ann T.; Cohen, Taylor S.; Tkaczyk, Christine; Sellman, Bret R.; Miller, Lloyd S.

In: Antimicrobial agents and chemotherapy, Vol. 63, No. 8, 01.08.2019.

Research output: Contribution to journalArticle

Ortines, RV, Wang, Y, Liu, H, Dikeman, DA, Pinsker, BL, Miller, RJ, Kim, SE, Ackerman, NE, Rizkallah, JF, Marcello, LAT, Cohen, TS, Tkaczyk, C, Sellman, BR & Miller, LS 2019, 'Efficacy of a Multimechanistic Monoclonal Antibody Combination against Staphylococcus aureus Surgical Site Infections in Mice', Antimicrobial agents and chemotherapy, vol. 63, no. 8. https://doi.org/10.1128/AAC.00346-19
Ortines, Roger V. ; Wang, Yu ; Liu, Haiyun ; Dikeman, Dustin A. ; Pinsker, Bret L. ; Miller, Robert J. ; Kim, Sophia E. ; Ackerman, Nicole E. ; Rizkallah, Joe F. ; Marcello, Lee Ann T. ; Cohen, Taylor S. ; Tkaczyk, Christine ; Sellman, Bret R. ; Miller, Lloyd S. / Efficacy of a Multimechanistic Monoclonal Antibody Combination against Staphylococcus aureus Surgical Site Infections in Mice. In: Antimicrobial agents and chemotherapy. 2019 ; Vol. 63, No. 8.
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