Abstract
Surgical site infections (SSIs) are commonly caused by Staphylococcus aureus We report that a combination of three monoclonal antibodies (MEDI6389) that neutralize S. aureus alpha-toxin, clumping factor A, and four leukocidins (LukSF, LukED, HlgAB, and HlgCB) plus vancomycin had enhanced efficacy compared with control antibody plus vancomycin in two mouse models of S. aureus SSI. Therefore, monoclonal antibody-based neutralization of multiple S. aureus virulence factors may provide an adjunctive perioperative approach to combat S. aureus SSIs.
| Original language | English (US) |
|---|---|
| Journal | Antimicrobial agents and chemotherapy |
| Volume | 63 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 1 2019 |
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Keywords
- alpha-toxin
- ClfA
- clumping factor A
- hla
- leukocidin
- MRSA
- Staphylococcus aureus
- surgical
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases
Cite this
Efficacy of a Multimechanistic Monoclonal Antibody Combination against Staphylococcus aureus Surgical Site Infections in Mice. / Ortines, Roger V.; Wang, Yu; Liu, Haiyun; Dikeman, Dustin A.; Pinsker, Bret L.; Miller, Robert J.; Kim, Sophia E.; Ackerman, Nicole E.; Rizkallah, Joe F.; Marcello, Lee Ann T.; Cohen, Taylor S.; Tkaczyk, Christine; Sellman, Bret R.; Miller, Lloyd S.
In: Antimicrobial agents and chemotherapy, Vol. 63, No. 8, 01.08.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Efficacy of a Multimechanistic Monoclonal Antibody Combination against Staphylococcus aureus Surgical Site Infections in Mice
AU - Ortines, Roger V.
AU - Wang, Yu
AU - Liu, Haiyun
AU - Dikeman, Dustin A.
AU - Pinsker, Bret L.
AU - Miller, Robert J.
AU - Kim, Sophia E.
AU - Ackerman, Nicole E.
AU - Rizkallah, Joe F.
AU - Marcello, Lee Ann T.
AU - Cohen, Taylor S.
AU - Tkaczyk, Christine
AU - Sellman, Bret R.
AU - Miller, Lloyd S
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Surgical site infections (SSIs) are commonly caused by Staphylococcus aureus We report that a combination of three monoclonal antibodies (MEDI6389) that neutralize S. aureus alpha-toxin, clumping factor A, and four leukocidins (LukSF, LukED, HlgAB, and HlgCB) plus vancomycin had enhanced efficacy compared with control antibody plus vancomycin in two mouse models of S. aureus SSI. Therefore, monoclonal antibody-based neutralization of multiple S. aureus virulence factors may provide an adjunctive perioperative approach to combat S. aureus SSIs.
AB - Surgical site infections (SSIs) are commonly caused by Staphylococcus aureus We report that a combination of three monoclonal antibodies (MEDI6389) that neutralize S. aureus alpha-toxin, clumping factor A, and four leukocidins (LukSF, LukED, HlgAB, and HlgCB) plus vancomycin had enhanced efficacy compared with control antibody plus vancomycin in two mouse models of S. aureus SSI. Therefore, monoclonal antibody-based neutralization of multiple S. aureus virulence factors may provide an adjunctive perioperative approach to combat S. aureus SSIs.
KW - alpha-toxin
KW - ClfA
KW - clumping factor A
KW - hla
KW - leukocidin
KW - MRSA
KW - Staphylococcus aureus
KW - surgical
UR - http://www.scopus.com/inward/record.url?scp=85070659723&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85070659723&partnerID=8YFLogxK
U2 - 10.1128/AAC.00346-19
DO - 10.1128/AAC.00346-19
M3 - Article
C2 - 31138566
AN - SCOPUS:85070659723
VL - 63
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 8
ER -