Efficacy of a live oral typhoid vaccine in human volunteers.

R. B. Hornick, H. L. DuPont, M. M. Levine, Robert H Gilman, W. E. Woodward, M. J. Snyder, T. E. Woodward

Research output: Contribution to journalArticle

Abstract

A live oral attenuated vaccine, lacking the enzyme epimerase, has been given with complete safety to 173 men. Two preparations of the vaccine, one with and one without galactose in the initial culture media, led to somewhat differing results. Vaccine A, prepared with galactose, was more readily identified in the stool specimens of its recipients and was more likely to provoke an O antibody response than was vaccine B. Furthermore, the clinical protection from typhoid fever was significant in the vaccine A group, whereas not so with the vaccine B counterpart. The protection afforded by vaccine A exceeds that of any of our previous candidate strains. It is perhaps not presumptuous to imagine that such a vaccine would be equally effective in an area endemic for typhoid fever, where the vaccine might act as a booster effect in a previously exposed population. Remaining questions to be answered include the duration of the protection, and the efficacy of a lyophilized preparation.

Original languageEnglish (US)
Pages (from-to)89-92
Number of pages4
JournalDevelopments in Biological Standardization
Volume33
StatePublished - 1976
Externally publishedYes

Fingerprint

Typhoid-Paratyphoid Vaccines
Volunteers
Vaccines
Typhoid Fever
Galactose
Racemases and Epimerases
Attenuated Vaccines
Antibody Formation
Culture Media
Safety
Enzymes

ASJC Scopus subject areas

  • Biotechnology

Cite this

Hornick, R. B., DuPont, H. L., Levine, M. M., Gilman, R. H., Woodward, W. E., Snyder, M. J., & Woodward, T. E. (1976). Efficacy of a live oral typhoid vaccine in human volunteers. Developments in Biological Standardization, 33, 89-92.

Efficacy of a live oral typhoid vaccine in human volunteers. / Hornick, R. B.; DuPont, H. L.; Levine, M. M.; Gilman, Robert H; Woodward, W. E.; Snyder, M. J.; Woodward, T. E.

In: Developments in Biological Standardization, Vol. 33, 1976, p. 89-92.

Research output: Contribution to journalArticle

Hornick, RB, DuPont, HL, Levine, MM, Gilman, RH, Woodward, WE, Snyder, MJ & Woodward, TE 1976, 'Efficacy of a live oral typhoid vaccine in human volunteers.', Developments in Biological Standardization, vol. 33, pp. 89-92.
Hornick RB, DuPont HL, Levine MM, Gilman RH, Woodward WE, Snyder MJ et al. Efficacy of a live oral typhoid vaccine in human volunteers. Developments in Biological Standardization. 1976;33:89-92.
Hornick, R. B. ; DuPont, H. L. ; Levine, M. M. ; Gilman, Robert H ; Woodward, W. E. ; Snyder, M. J. ; Woodward, T. E. / Efficacy of a live oral typhoid vaccine in human volunteers. In: Developments in Biological Standardization. 1976 ; Vol. 33. pp. 89-92.
@article{de91b104e1c6444f9c3ed997f083855d,
title = "Efficacy of a live oral typhoid vaccine in human volunteers.",
abstract = "A live oral attenuated vaccine, lacking the enzyme epimerase, has been given with complete safety to 173 men. Two preparations of the vaccine, one with and one without galactose in the initial culture media, led to somewhat differing results. Vaccine A, prepared with galactose, was more readily identified in the stool specimens of its recipients and was more likely to provoke an O antibody response than was vaccine B. Furthermore, the clinical protection from typhoid fever was significant in the vaccine A group, whereas not so with the vaccine B counterpart. The protection afforded by vaccine A exceeds that of any of our previous candidate strains. It is perhaps not presumptuous to imagine that such a vaccine would be equally effective in an area endemic for typhoid fever, where the vaccine might act as a booster effect in a previously exposed population. Remaining questions to be answered include the duration of the protection, and the efficacy of a lyophilized preparation.",
author = "Hornick, {R. B.} and DuPont, {H. L.} and Levine, {M. M.} and Gilman, {Robert H} and Woodward, {W. E.} and Snyder, {M. J.} and Woodward, {T. E.}",
year = "1976",
language = "English (US)",
volume = "33",
pages = "89--92",
journal = "Developments in Biological Standardization",
issn = "0301-5149",
publisher = "S. Karger AG",

}

TY - JOUR

T1 - Efficacy of a live oral typhoid vaccine in human volunteers.

AU - Hornick, R. B.

AU - DuPont, H. L.

AU - Levine, M. M.

AU - Gilman, Robert H

AU - Woodward, W. E.

AU - Snyder, M. J.

AU - Woodward, T. E.

PY - 1976

Y1 - 1976

N2 - A live oral attenuated vaccine, lacking the enzyme epimerase, has been given with complete safety to 173 men. Two preparations of the vaccine, one with and one without galactose in the initial culture media, led to somewhat differing results. Vaccine A, prepared with galactose, was more readily identified in the stool specimens of its recipients and was more likely to provoke an O antibody response than was vaccine B. Furthermore, the clinical protection from typhoid fever was significant in the vaccine A group, whereas not so with the vaccine B counterpart. The protection afforded by vaccine A exceeds that of any of our previous candidate strains. It is perhaps not presumptuous to imagine that such a vaccine would be equally effective in an area endemic for typhoid fever, where the vaccine might act as a booster effect in a previously exposed population. Remaining questions to be answered include the duration of the protection, and the efficacy of a lyophilized preparation.

AB - A live oral attenuated vaccine, lacking the enzyme epimerase, has been given with complete safety to 173 men. Two preparations of the vaccine, one with and one without galactose in the initial culture media, led to somewhat differing results. Vaccine A, prepared with galactose, was more readily identified in the stool specimens of its recipients and was more likely to provoke an O antibody response than was vaccine B. Furthermore, the clinical protection from typhoid fever was significant in the vaccine A group, whereas not so with the vaccine B counterpart. The protection afforded by vaccine A exceeds that of any of our previous candidate strains. It is perhaps not presumptuous to imagine that such a vaccine would be equally effective in an area endemic for typhoid fever, where the vaccine might act as a booster effect in a previously exposed population. Remaining questions to be answered include the duration of the protection, and the efficacy of a lyophilized preparation.

UR - http://www.scopus.com/inward/record.url?scp=0016914944&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016914944&partnerID=8YFLogxK

M3 - Article

C2 - 782976

AN - SCOPUS:0016914944

VL - 33

SP - 89

EP - 92

JO - Developments in Biological Standardization

JF - Developments in Biological Standardization

SN - 0301-5149

ER -