Efficacy and safety of pneumatic dilatation for achalasia i. The treatment of post-myotomy symptom relapse

Vivek Kumbhari, Jason Behary, Michal Szczesniak, Teng Zhang, Ian J. Cook

Research output: Contribution to journalArticle

Abstract

Objectives::There is no consensus on how best to treat symptom recurrence following previous therapy with Heller myotomy. Our aim was to determin. The safety an. The short and long-term efficacy of pneumatic dilatation to treat symptomatic recurrence in patients previously treated with Heller myotomy for idiopathic achalasia. Methods:We identified 27 eligible patients treated with pneumatic dilatation, for symptom recurrence following Heller myotomy as their initial or secondary treatment, from a prospectively acquired database of 450 patients with a diagnosis of achalasia seen between 1995 and 2010. Our treatment protocol involved sequential, graded pneumatic dilatations (30-35-40 mm) over a 2-6 week period until an initial therapeutic response was achieved. The subsequent relapse rate, defined a. The need for any subsequent therapy, was determined. Relapsers were offered further pneumatic dilatation "on demand". A cross-sectional analysis was also performed using a validated achalasia severity questionnaire to determin. The overall long-term remission rate. Results:Of 27 eligible patients, 25 (93%) complied wit. The institutional dilatation protocol. The two drop-outs did so afte. The initial 30 mm dilatation and were deemed treatment failures. One additional patient did not respond despite protocol compliance. Therefore, 24 of 27 (89%) patients were responders on intention to treat analysis at 12 months, whil. The per protocol response rate was 24 of 25 (96%). Amon. The 24 responders 16, 25, and 42% relapsed at 2, 3 and 4 years, respectively. Overall long-term remission, with on demand dilatations as required, was 95% (median follow-up 30 months). There were no perforations in a total of 50 dilatations in 27 patients.CONCLUSIONS:In treating symptom recurrence, following prior Heller myotomy, pneumatic dilatation is safe and yields an excellent short-term response rate. Althoug. The long-term relapse rate is substantial, subsequent on demand pneumatic dilatation in this population is highly effective with a long-term remission rate of 95%. These data also highligh. The need to keep these patients under long-term review.

Original languageEnglish (US)
Pages (from-to)1076-1081
Number of pages6
JournalAmerican Journal of Gastroenterology
Volume108
Issue number7
DOIs
StatePublished - Jul 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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