Efficacy and safety of low-dose topical tacrolimus in vernal keratoconjunctivitis

Samir S. Shoughy, Mahmoud O. Jaroudi, Khalid F. Tabbara

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Objective: The objective of this study was to evaluate the efficacy and safety of topical low-dose tacrolimus (0.01%) solution in patients with vernal keratoconjunctivitis (VKC). Patients and methods: A total of 62 consecutive patients with VKC refractory to conventional treatment were included retrospectively. Tacrolimus 0.01% ophthalmic solution was administered to patients twice daily after discontinuation of all previous topical medications. The duration of treatment ranged from 1 month to 29 months. The clinical symptoms of itching, redness, foreign body sensation, and discharge and the clinical signs of conjunctival hyperemia, conjunctival papillary hypertrophy, limbal infiltration, Trantas dots, and superficial punctate keratopathy were graded as 0 (normal), 1+ (mild), 2+ (moderate), or 3+ (severe). Assessment was carried out before initiation of therapy and on the last visit after treatment. Results: There were 62 patients with VKC comprising 49 male and 13 female patients. The median age was 12 years (range: 5-47 years). The mean visual acuity improved from 20/30 to 20/25 following treatment. There was statistically significant improvement in symptoms of itching (P

Original languageEnglish (US)
Pages (from-to)643-647
Number of pages5
JournalClinical Ophthalmology
StatePublished - Apr 7 2016


  • Solution
  • Tacrolimus
  • Topical
  • Vernal keratoconjunctivitis

ASJC Scopus subject areas

  • Ophthalmology


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