@article{4dc2a23b9f8340ab8f4410d8e51f2ff2,
title = "Efficacy and safety of long-term phenobarbital therapy of familial cholestasis",
abstract = "Two brothers with progressive familial intraheptic cholestasis were followed during four years of phenobarbital therapy to assess its long-term safety and efficacy. Effects attributable to phenobarbital included sustained relief of pruritus, lowering of serum bilirubin levels, and enhanced hepatic excretion of 131I-rose bengal; serum bile acid levels were only transiently decreased. Two brief interruptions in therapy resulted in symptomatic deterioration. Phenobarbital did not retard growth nor impede the response to vitamin D therapy of concomitant rickets.",
author = "Ghent, {C. N.} and Bloomer, {J. R.} and Hsia, {Y. E.} and Lietman, {Paul S.}",
note = "Funding Information: From the Departments of Medicbw and Hmnan Genetics, }'ale Universit){"} School of Medicine. Supported in part b)': Childrens Clinical Research Grant RR 125, Public Health Service Center Grant GN 20124, Training Grant 1LD. 00198, National Foundation-March of Dhnes MedJ'cal Service Grant C-143, attd United States Public Health Service Trahting Grant AM 5180-15. Dr. Ghent was supported b){"} the R. Samuel McLaughlin Foundation and the Canadian Hepatic ~btmdation. Dr. Bloomer is an Investigator. Howard Hughes Medical hlstitute. {"}Reprint address: Department of Medicine, Universitr llospital. London, Ontario. Canada. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",
year = "1978",
month = jul,
doi = "10.1016/S0022-3476(78)80625-8",
language = "English (US)",
volume = "93",
pages = "127--132",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "1",
}