Efficacy and safety of long-term phenobarbital therapy of familial cholestasis

C. N. Ghent, J. R. Bloomer, Y. E. Hsia, Paul S. Lietman

Research output: Contribution to journalArticlepeer-review


Two brothers with progressive familial intraheptic cholestasis were followed during four years of phenobarbital therapy to assess its long-term safety and efficacy. Effects attributable to phenobarbital included sustained relief of pruritus, lowering of serum bilirubin levels, and enhanced hepatic excretion of 131I-rose bengal; serum bile acid levels were only transiently decreased. Two brief interruptions in therapy resulted in symptomatic deterioration. Phenobarbital did not retard growth nor impede the response to vitamin D therapy of concomitant rickets.

Original languageEnglish (US)
Pages (from-to)127-132
Number of pages6
JournalThe Journal of pediatrics
Issue number1
StatePublished - Jul 1978

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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