Abstract
Two brothers with progressive familial intraheptic cholestasis were followed during four years of phenobarbital therapy to assess its long-term safety and efficacy. Effects attributable to phenobarbital included sustained relief of pruritus, lowering of serum bilirubin levels, and enhanced hepatic excretion of 131I-rose bengal; serum bile acid levels were only transiently decreased. Two brief interruptions in therapy resulted in symptomatic deterioration. Phenobarbital did not retard growth nor impede the response to vitamin D therapy of concomitant rickets.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 127-132 |
| Number of pages | 6 |
| Journal | Journal of Pediatrics |
| Volume | 93 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1978 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
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Efficacy and safety of long-term phenobarbital therapy of familial cholestasis. / Ghent, C. N.; Bloomer, J. R.; Hsia, Y. E.; Lietman, Paul S.
In: Journal of Pediatrics, Vol. 93, No. 1, 1978, p. 127-132.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Efficacy and safety of long-term phenobarbital therapy of familial cholestasis
AU - Ghent, C. N.
AU - Bloomer, J. R.
AU - Hsia, Y. E.
AU - Lietman, Paul S.
PY - 1978
Y1 - 1978
N2 - Two brothers with progressive familial intraheptic cholestasis were followed during four years of phenobarbital therapy to assess its long-term safety and efficacy. Effects attributable to phenobarbital included sustained relief of pruritus, lowering of serum bilirubin levels, and enhanced hepatic excretion of 131I-rose bengal; serum bile acid levels were only transiently decreased. Two brief interruptions in therapy resulted in symptomatic deterioration. Phenobarbital did not retard growth nor impede the response to vitamin D therapy of concomitant rickets.
AB - Two brothers with progressive familial intraheptic cholestasis were followed during four years of phenobarbital therapy to assess its long-term safety and efficacy. Effects attributable to phenobarbital included sustained relief of pruritus, lowering of serum bilirubin levels, and enhanced hepatic excretion of 131I-rose bengal; serum bile acid levels were only transiently decreased. Two brief interruptions in therapy resulted in symptomatic deterioration. Phenobarbital did not retard growth nor impede the response to vitamin D therapy of concomitant rickets.
UR - http://www.scopus.com/inward/record.url?scp=0017810790&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017810790&partnerID=8YFLogxK
U2 - 10.1016/S0022-3476(78)80625-8
DO - 10.1016/S0022-3476(78)80625-8
M3 - Article
C2 - 650323
AN - SCOPUS:0017810790
VL - 93
SP - 127
EP - 132
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 1
ER -