Efficacy and safety of long-term phenobarbital therapy of familial cholestasis

C. N. Ghent, J. R. Bloomer, Y. E. Hsia, Paul S. Lietman

Research output: Contribution to journalArticle

Abstract

Two brothers with progressive familial intraheptic cholestasis were followed during four years of phenobarbital therapy to assess its long-term safety and efficacy. Effects attributable to phenobarbital included sustained relief of pruritus, lowering of serum bilirubin levels, and enhanced hepatic excretion of 131I-rose bengal; serum bile acid levels were only transiently decreased. Two brief interruptions in therapy resulted in symptomatic deterioration. Phenobarbital did not retard growth nor impede the response to vitamin D therapy of concomitant rickets.

Original languageEnglish (US)
Pages (from-to)127-132
Number of pages6
JournalJournal of Pediatrics
Volume93
Issue number1
DOIs
StatePublished - 1978
Externally publishedYes

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Cholestasis
Phenobarbital
Safety
Rose Bengal
Rickets
Pruritus
Bile Acids and Salts
Serum
Bilirubin
Vitamin D
Therapeutics
Growth

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Efficacy and safety of long-term phenobarbital therapy of familial cholestasis. / Ghent, C. N.; Bloomer, J. R.; Hsia, Y. E.; Lietman, Paul S.

In: Journal of Pediatrics, Vol. 93, No. 1, 1978, p. 127-132.

Research output: Contribution to journalArticle

Ghent, C. N. ; Bloomer, J. R. ; Hsia, Y. E. ; Lietman, Paul S. / Efficacy and safety of long-term phenobarbital therapy of familial cholestasis. In: Journal of Pediatrics. 1978 ; Vol. 93, No. 1. pp. 127-132.
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