Efficacy and safety of generic amphotericin B in experimental pulmonary aspergillosis

Vidmantas Petraitis, Ruta Petraitiene, Pengxin Lin, Karim Calis, Amy M. Kelaher, Heidi A. Muray, Christine Mya-San, Diana Mickiene, John Bacher, Thomas J. Walsh

Research output: Contribution to journalArticle

Abstract

The recent shortage of the brand name drug Fungizone has necessitated a change to generic formulations of amphotericin B deoxycholate. Clinical trials cannot be conducted in a timely manner to provide data on the safety and efficacy of these formulations. We therefore compared generic amphotericin B and Fungizone for activity and safety in the treatment of experimental invasive pulmonary aspergillosis (IPA) in persistently neutropenic rabbits. Fungizone and generic amphotericin B are similar in efficacy, pharmacokinetics, and safety in the treatment of experimental IPA.

Original languageEnglish (US)
Pages (from-to)1642-1645
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume49
Issue number4
DOIs
StatePublished - Apr 2005
Externally publishedYes

Fingerprint

Pulmonary Aspergillosis
Amphotericin B
Safety
Invasive Pulmonary Aspergillosis
Names
Pharmacokinetics
Clinical Trials
Rabbits
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Petraitis, V., Petraitiene, R., Lin, P., Calis, K., Kelaher, A. M., Muray, H. A., ... Walsh, T. J. (2005). Efficacy and safety of generic amphotericin B in experimental pulmonary aspergillosis. Antimicrobial Agents and Chemotherapy, 49(4), 1642-1645. https://doi.org/10.1128/AAC.49.4.1642-1645.2005

Efficacy and safety of generic amphotericin B in experimental pulmonary aspergillosis. / Petraitis, Vidmantas; Petraitiene, Ruta; Lin, Pengxin; Calis, Karim; Kelaher, Amy M.; Muray, Heidi A.; Mya-San, Christine; Mickiene, Diana; Bacher, John; Walsh, Thomas J.

In: Antimicrobial Agents and Chemotherapy, Vol. 49, No. 4, 04.2005, p. 1642-1645.

Research output: Contribution to journalArticle

Petraitis, V, Petraitiene, R, Lin, P, Calis, K, Kelaher, AM, Muray, HA, Mya-San, C, Mickiene, D, Bacher, J & Walsh, TJ 2005, 'Efficacy and safety of generic amphotericin B in experimental pulmonary aspergillosis', Antimicrobial Agents and Chemotherapy, vol. 49, no. 4, pp. 1642-1645. https://doi.org/10.1128/AAC.49.4.1642-1645.2005
Petraitis, Vidmantas ; Petraitiene, Ruta ; Lin, Pengxin ; Calis, Karim ; Kelaher, Amy M. ; Muray, Heidi A. ; Mya-San, Christine ; Mickiene, Diana ; Bacher, John ; Walsh, Thomas J. / Efficacy and safety of generic amphotericin B in experimental pulmonary aspergillosis. In: Antimicrobial Agents and Chemotherapy. 2005 ; Vol. 49, No. 4. pp. 1642-1645.
@article{45891fc158bd4460b1df040b2589f0cb,
title = "Efficacy and safety of generic amphotericin B in experimental pulmonary aspergillosis",
abstract = "The recent shortage of the brand name drug Fungizone has necessitated a change to generic formulations of amphotericin B deoxycholate. Clinical trials cannot be conducted in a timely manner to provide data on the safety and efficacy of these formulations. We therefore compared generic amphotericin B and Fungizone for activity and safety in the treatment of experimental invasive pulmonary aspergillosis (IPA) in persistently neutropenic rabbits. Fungizone and generic amphotericin B are similar in efficacy, pharmacokinetics, and safety in the treatment of experimental IPA.",
author = "Vidmantas Petraitis and Ruta Petraitiene and Pengxin Lin and Karim Calis and Kelaher, {Amy M.} and Muray, {Heidi A.} and Christine Mya-San and Diana Mickiene and John Bacher and Walsh, {Thomas J.}",
year = "2005",
month = "4",
doi = "10.1128/AAC.49.4.1642-1645.2005",
language = "English (US)",
volume = "49",
pages = "1642--1645",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "4",

}

TY - JOUR

T1 - Efficacy and safety of generic amphotericin B in experimental pulmonary aspergillosis

AU - Petraitis, Vidmantas

AU - Petraitiene, Ruta

AU - Lin, Pengxin

AU - Calis, Karim

AU - Kelaher, Amy M.

AU - Muray, Heidi A.

AU - Mya-San, Christine

AU - Mickiene, Diana

AU - Bacher, John

AU - Walsh, Thomas J.

PY - 2005/4

Y1 - 2005/4

N2 - The recent shortage of the brand name drug Fungizone has necessitated a change to generic formulations of amphotericin B deoxycholate. Clinical trials cannot be conducted in a timely manner to provide data on the safety and efficacy of these formulations. We therefore compared generic amphotericin B and Fungizone for activity and safety in the treatment of experimental invasive pulmonary aspergillosis (IPA) in persistently neutropenic rabbits. Fungizone and generic amphotericin B are similar in efficacy, pharmacokinetics, and safety in the treatment of experimental IPA.

AB - The recent shortage of the brand name drug Fungizone has necessitated a change to generic formulations of amphotericin B deoxycholate. Clinical trials cannot be conducted in a timely manner to provide data on the safety and efficacy of these formulations. We therefore compared generic amphotericin B and Fungizone for activity and safety in the treatment of experimental invasive pulmonary aspergillosis (IPA) in persistently neutropenic rabbits. Fungizone and generic amphotericin B are similar in efficacy, pharmacokinetics, and safety in the treatment of experimental IPA.

UR - http://www.scopus.com/inward/record.url?scp=20144389443&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20144389443&partnerID=8YFLogxK

U2 - 10.1128/AAC.49.4.1642-1645.2005

DO - 10.1128/AAC.49.4.1642-1645.2005

M3 - Article

C2 - 15793161

AN - SCOPUS:20144389443

VL - 49

SP - 1642

EP - 1645

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 4

ER -