Efficacy and safety of generic amphotericin B in experimental pulmonary aspergillosis

Vidmantas Petraitis; Ruta Petraitiene; Pengxin Lin; Karim Calis; Amy M. Kelaher; Heidi A. Muray; Christine Mya-San; Diana Mickiene; John Bacher; Thomas J. Walsh

doi:10.1128/AAC.49.4.1642-1645.2005

Efficacy and safety of generic amphotericin B in experimental pulmonary aspergillosis

Vidmantas Petraitis, Ruta Petraitiene, Pengxin Lin, Karim Calis, Amy M. Kelaher, Heidi A. Muray, Christine Mya-San, Diana Mickiene, John Bacher, Thomas J. Walsh

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The recent shortage of the brand name drug Fungizone has necessitated a change to generic formulations of amphotericin B deoxycholate. Clinical trials cannot be conducted in a timely manner to provide data on the safety and efficacy of these formulations. We therefore compared generic amphotericin B and Fungizone for activity and safety in the treatment of experimental invasive pulmonary aspergillosis (IPA) in persistently neutropenic rabbits. Fungizone and generic amphotericin B are similar in efficacy, pharmacokinetics, and safety in the treatment of experimental IPA.

Original language	English (US)
Pages (from-to)	1642-1645
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	49
Issue number	4
DOIs	https://doi.org/10.1128/AAC.49.4.1642-1645.2005
State	Published - Apr 2005
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.49.4.1642-1645.2005

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abstract = "The recent shortage of the brand name drug Fungizone has necessitated a change to generic formulations of amphotericin B deoxycholate. Clinical trials cannot be conducted in a timely manner to provide data on the safety and efficacy of these formulations. We therefore compared generic amphotericin B and Fungizone for activity and safety in the treatment of experimental invasive pulmonary aspergillosis (IPA) in persistently neutropenic rabbits. Fungizone and generic amphotericin B are similar in efficacy, pharmacokinetics, and safety in the treatment of experimental IPA.",

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AU - Petraitis, Vidmantas

AU - Petraitiene, Ruta

AU - Lin, Pengxin

AU - Calis, Karim

AU - Kelaher, Amy M.

AU - Muray, Heidi A.

AU - Mya-San, Christine

AU - Mickiene, Diana

AU - Bacher, John

AU - Walsh, Thomas J.

PY - 2005/4

Y1 - 2005/4

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AB - The recent shortage of the brand name drug Fungizone has necessitated a change to generic formulations of amphotericin B deoxycholate. Clinical trials cannot be conducted in a timely manner to provide data on the safety and efficacy of these formulations. We therefore compared generic amphotericin B and Fungizone for activity and safety in the treatment of experimental invasive pulmonary aspergillosis (IPA) in persistently neutropenic rabbits. Fungizone and generic amphotericin B are similar in efficacy, pharmacokinetics, and safety in the treatment of experimental IPA.

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Efficacy and safety of generic amphotericin B in experimental pulmonary aspergillosis

Abstract

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