Efficacy and safety of five injectable anesthetic regimens for chronic blood collection from the anterior vena cava of guinea pigs

Vi Dang, Saran Bao, Alida Ault, Catherine Murray, Joy McFarlane-Mills, Carmelo Chiedi, Marlon Dillon, John Paul Todd, Louis DeTolla, Srinivas Rao

Research output: Contribution to journalArticle

Abstract

Despite several published methods of inducing surgical anesthesia in guinea pigs, viable methods of anesthesia for blood collection from the vena cava are inadequate. We compared 5 anesthesia regimens and their efficacy in inducing anesthesia for blood sampling in guinea pigs: ketamine-xylazine (30 and 2.5 mg/kg) administered subcutaneously, intramuscularly, or intraperitoneally; pentobarbital (37 mg/kg) administered intraperitoneally; and medetomidine (0.5 mg/kg) administered intramuscularly. Parameters measured included time to onset of anesthesia, time to recovery from anesthesia, and complete blood count (CBC) and serum chemistry values. CBC values did not differ among the 5 regimens, but serum glucose, BUN, phosphorous, and creatine phosphokinase levels varied among groups. Based on our data, intraperitoneal ketamine-xylazine appears to emerge as a preferable injectable anesthetic regimen in guinea pigs for blood collection from the anterior vena cava.

Original languageEnglish (US)
Pages (from-to)56-60
Number of pages5
JournalJournal of the American Association for Laboratory Animal Science
Volume47
Issue number6
StatePublished - Nov 1 2008

    Fingerprint

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Dang, V., Bao, S., Ault, A., Murray, C., McFarlane-Mills, J., Chiedi, C., Dillon, M., Todd, J. P., DeTolla, L., & Rao, S. (2008). Efficacy and safety of five injectable anesthetic regimens for chronic blood collection from the anterior vena cava of guinea pigs. Journal of the American Association for Laboratory Animal Science, 47(6), 56-60.