Efficacies of four antifungal agents in experimental murine sporotrichosis

V. L. Kan, J. E. Bennett

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Four antifungal agents, amphotericin B, SDZ 89-485, itraconazole, and terbinafine, were tested for efficacy in a murine model of systemic sporotrichosis. Survival in the groups treated with amphotericin B, SDZ 89-485, and itraconazole was significantly better than that of control infected mice. However, these agents did not wholly protect the infected mice, as tail and paw lesions, whole-body radiographs, and positive cultures from survivors showed evidence of dissemination. Terbinafine-treated mice had the same or poorer survival as control infected mice, despite documented drug absorption.

Original languageEnglish (US)
Pages (from-to)1619-1623
Number of pages5
JournalAntimicrobial agents and chemotherapy
Issue number11
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases


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