Efficacies of clarithromycin regimens against Mycobacterium xenopi in mice

N. Lounis, C. Truffot-Pernot, A. Bentoucha, J. Robert, B. Ji, J. Grosset

Research output: Contribution to journalArticle

Abstract

Mice were infected intravenously with 3.5 × 107 CFU of Mycobacterium xenopi and treated with various clarithromycin-containing regimens or left untreated for 4 weeks. All nine of the clarithromycin-containing regimens reduced the CFU counts to the levels below the pretreatment values, indicating that these regimens had a bactericidal effect on M. xenopi in mice. The rifampin-isoniazid-ethambutol regimen was significantly less bactericidal than clarithromycin alone or clarithromycin-containing combined regimens.

Original languageEnglish (US)
Pages (from-to)3229-3230
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Volume45
Issue number11
DOIs
StatePublished - 2001
Externally publishedYes

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Mycobacterium xenopi
Clarithromycin
Ethambutol
Isoniazid
Rifampin

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Lounis, N., Truffot-Pernot, C., Bentoucha, A., Robert, J., Ji, B., & Grosset, J. (2001). Efficacies of clarithromycin regimens against Mycobacterium xenopi in mice. Antimicrobial Agents and Chemotherapy, 45(11), 3229-3230. https://doi.org/10.1128/AAC.45.11.3229-3230.2001

Efficacies of clarithromycin regimens against Mycobacterium xenopi in mice. / Lounis, N.; Truffot-Pernot, C.; Bentoucha, A.; Robert, J.; Ji, B.; Grosset, J.

In: Antimicrobial Agents and Chemotherapy, Vol. 45, No. 11, 2001, p. 3229-3230.

Research output: Contribution to journalArticle

Lounis, N, Truffot-Pernot, C, Bentoucha, A, Robert, J, Ji, B & Grosset, J 2001, 'Efficacies of clarithromycin regimens against Mycobacterium xenopi in mice', Antimicrobial Agents and Chemotherapy, vol. 45, no. 11, pp. 3229-3230. https://doi.org/10.1128/AAC.45.11.3229-3230.2001
Lounis, N. ; Truffot-Pernot, C. ; Bentoucha, A. ; Robert, J. ; Ji, B. ; Grosset, J. / Efficacies of clarithromycin regimens against Mycobacterium xenopi in mice. In: Antimicrobial Agents and Chemotherapy. 2001 ; Vol. 45, No. 11. pp. 3229-3230.
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