Efficacies of clarithromycin regimens against Mycobacterium xenopi in mice

N. Lounis, C. Truffot-Pernot, A. Bentoucha, J. Robert, B. Ji, J. Grosset

Research output: Contribution to journalArticlepeer-review

Abstract

Mice were infected intravenously with 3.5 × 107 CFU of Mycobacterium xenopi and treated with various clarithromycin-containing regimens or left untreated for 4 weeks. All nine of the clarithromycin-containing regimens reduced the CFU counts to the levels below the pretreatment values, indicating that these regimens had a bactericidal effect on M. xenopi in mice. The rifampin-isoniazid-ethambutol regimen was significantly less bactericidal than clarithromycin alone or clarithromycin-containing combined regimens.

Original languageEnglish (US)
Pages (from-to)3229-3230
Number of pages2
JournalAntimicrobial agents and chemotherapy
Volume45
Issue number11
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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