Efferent regulation of hair cells in the turtle cochlea

J. J. Art, A. C. Crawford, R. Fettiplace, Paul Albert Fuchs

Research output: Contribution to journalArticle

Abstract

Intracellular recordings were made from hair cells in the isolated cochlea of the turtle to characterize the inhibition achieved by the cochlea's efferent innervation. A short train of shocks delivered to the efferent axons produced in the hair cells slow hyperpolarizing synaptic potentials which could be reversed by shifting the membrane potential more negative than about -80 mV. Throughout the efferent hyperpolarization there was a reduction of up to 25-fold in the amplitude of the receptor potential for tones presented at the hair cell's characteristic frequency. Efferent stimulation also was shown to degrade the cell's tuning properties. It is argued that the combined effects of the hyperpolarization and the loss in hair cell sensitivity could account for a threshold elevation of at least 70 dB in the auditory nerve fibres.

Original languageEnglish (US)
Pages (from-to)377-384
Number of pages8
JournalProceedings of the Royal Society B: Biological Sciences
Volume216
Issue number1204
StatePublished - 1982
Externally publishedYes

Fingerprint

Turtles
Cochlea
hair
turtle
turtles
hairs
Cells
cells
Cochlear Nerve
Synaptic Potentials
alopecia
train
Alopecia
nerve fibers
innervation
Nerve Fibers
membrane potential
Tuning
axons
Membrane Potentials

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)

Cite this

Efferent regulation of hair cells in the turtle cochlea. / Art, J. J.; Crawford, A. C.; Fettiplace, R.; Fuchs, Paul Albert.

In: Proceedings of the Royal Society B: Biological Sciences, Vol. 216, No. 1204, 1982, p. 377-384.

Research output: Contribution to journalArticle

Art, J. J. ; Crawford, A. C. ; Fettiplace, R. ; Fuchs, Paul Albert. / Efferent regulation of hair cells in the turtle cochlea. In: Proceedings of the Royal Society B: Biological Sciences. 1982 ; Vol. 216, No. 1204. pp. 377-384.
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