Abstract
The effects of the dicar{ballot box}ylic amino acid,dl-α-aminoadipate (DLAA) on amino acid responses have been investigated using intracellular recordings from mouse spinal cord neurons grown in dissociated cell culture.dl-α-Aminoadipate markedly antagonized postsynaptic responses to iontophoretically applied aspartate; antagonism of glutamate was much less prominent.dl-α-Aminoadipate altered the affinity of aspartate for its receptor while having no observed effects on aspartate-receptor cooperativity. No direct effects of DLAA on membrane potentials or passive membrane properties were seen at the currents used for antagonism. Responses to the inhibitory amino acids GABA and glycine were unaffected by DLAA.
Original language | English (US) |
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Pages (from-to) | 199-207 |
Number of pages | 9 |
Journal | Brain research |
Volume | 193 |
Issue number | 1 |
DOIs | |
State | Published - Jul 7 1980 |
Externally published | Yes |
Keywords
- amino acids
- aminoadipate
- aspartate
- cultured neurons
- spinal cord
ASJC Scopus subject areas
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology