Effects ofd,l-α-aminoadipate on postsynaptic amino acid responses in cultured mouse spinal cord neurons

Gregory K. Bergey, Michael R. Martin, Manfred Hermes

Research output: Contribution to journalArticle

Abstract

The effects of the dicar{ballot box}ylic amino acid,dl-α-aminoadipate (DLAA) on amino acid responses have been investigated using intracellular recordings from mouse spinal cord neurons grown in dissociated cell culture.dl-α-Aminoadipate markedly antagonized postsynaptic responses to iontophoretically applied aspartate; antagonism of glutamate was much less prominent.dl-α-Aminoadipate altered the affinity of aspartate for its receptor while having no observed effects on aspartate-receptor cooperativity. No direct effects of DLAA on membrane potentials or passive membrane properties were seen at the currents used for antagonism. Responses to the inhibitory amino acids GABA and glycine were unaffected by DLAA.

Original languageEnglish (US)
Pages (from-to)199-207
Number of pages9
JournalBrain research
Volume193
Issue number1
DOIs
StatePublished - Jul 7 1980
Externally publishedYes

Keywords

  • amino acids
  • aminoadipate
  • aspartate
  • cultured neurons
  • spinal cord

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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