Effects of yohimbine on heart rate variability in panic disorder patients and normal controls: A study of power spectral analysis of heart rate

Vikram K. Yeragani, Ronald D Berger, Robert Pohl, K. Srinivasan, Richard Balon, C. Ramesh, Paula Weinberg, Richard Berchou

Research output: Contribution to journalArticle


We studied the effects of yohimbine on heart rate (HR) variability in 13 normal controls and 13 patients with panic disorder. Yohimbine produced a significant increase in SD of HR in standing posture in both patients (p = 0.01) and normal controls (p = 0.025). Panic disorder patients had a significant increase in standing absolute midfrequency (MF) power (0.07–0.15 Hz) after administration of yohimbine (p = 0.002). The ratio of post- to preyohimbine standing MF power (0.07–0.15 Hz) during standing was significantly higher in patients as compared with controls (2.3 ± 1.08 vs. 1.33 ± 0.38; p = 0.01), which suggests an increased responsivity of panic disorder patients to the adrenergic effects of yohimbine.

Original languageEnglish (US)
Pages (from-to)609-618
Number of pages10
JournalJournal of Cardiovascular Pharmacology
Issue number4
Publication statusPublished - 1992



  • Heart rate variability
  • Normal controls
  • Panic disorder
  • Spectral analysis-sympathetic
  • Yohimbine

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

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