Effects of yohimbine on heart rate variability in panic disorder patients and normal controls: A study of power spectral analysis of heart rate

Vikram K. Yeragani; Ronald Berger; Robert Pohl; K. Srinivasan; Richard Balon; C. Ramesh; Paula Weinberg; Richard Berchou

doi:10.1097/00005344-199210000-00015

Effects of yohimbine on heart rate variability in panic disorder patients and normal controls: A study of power spectral analysis of heart rate

Vikram K. Yeragani, Ronald Berger, Robert Pohl, K. Srinivasan, Richard Balon, C. Ramesh, Paula Weinberg, Richard Berchou

Johns Hopkins Hospital

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

We studied the effects of yohimbine on heart rate (HR) variability in 13 normal controls and 13 patients with panic disorder. Yohimbine produced a significant increase in SD of HR in standing posture in both patients (p = 0.01) and normal controls (p = 0.025). Panic disorder patients had a significant increase in standing absolute midfrequency (MF) power (0.07–0.15 Hz) after administration of yohimbine (p = 0.002). The ratio of post- to preyohimbine standing MF power (0.07–0.15 Hz) during standing was significantly higher in patients as compared with controls (2.3 ± 1.08 vs. 1.33 ± 0.38; p = 0.01), which suggests an increased responsivity of panic disorder patients to the adrenergic effects of yohimbine.

Original language	English (US)
Pages (from-to)	609-618
Number of pages	10
Journal	Journal of cardiovascular pharmacology
Volume	20
Issue number	4
DOIs	https://doi.org/10.1097/00005344-199210000-00015
State	Published - Oct 1992

Keywords

Heart rate variability
Normal controls
Panic disorder
Spectral analysis-sympathetic
Yohimbine

ASJC Scopus subject areas

Pharmacology
Cardiology and Cardiovascular Medicine

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10.1097/00005344-199210000-00015

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title = "Effects of yohimbine on heart rate variability in panic disorder patients and normal controls: A study of power spectral analysis of heart rate",

abstract = "We studied the effects of yohimbine on heart rate (HR) variability in 13 normal controls and 13 patients with panic disorder. Yohimbine produced a significant increase in SD of HR in standing posture in both patients (p = 0.01) and normal controls (p = 0.025). Panic disorder patients had a significant increase in standing absolute midfrequency (MF) power (0.07–0.15 Hz) after administration of yohimbine (p = 0.002). The ratio of post- to preyohimbine standing MF power (0.07–0.15 Hz) during standing was significantly higher in patients as compared with controls (2.3 ± 1.08 vs. 1.33 ± 0.38; p = 0.01), which suggests an increased responsivity of panic disorder patients to the adrenergic effects of yohimbine.",

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author = "Yeragani, {Vikram K.} and Ronald Berger and Robert Pohl and K. Srinivasan and Richard Balon and C. Ramesh and Paula Weinberg and Richard Berchou",

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AU - Yeragani, Vikram K.

AU - Berger, Ronald

AU - Pohl, Robert

AU - Srinivasan, K.

AU - Balon, Richard

AU - Ramesh, C.

AU - Weinberg, Paula

AU - Berchou, Richard

PY - 1992/10

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N2 - We studied the effects of yohimbine on heart rate (HR) variability in 13 normal controls and 13 patients with panic disorder. Yohimbine produced a significant increase in SD of HR in standing posture in both patients (p = 0.01) and normal controls (p = 0.025). Panic disorder patients had a significant increase in standing absolute midfrequency (MF) power (0.07–0.15 Hz) after administration of yohimbine (p = 0.002). The ratio of post- to preyohimbine standing MF power (0.07–0.15 Hz) during standing was significantly higher in patients as compared with controls (2.3 ± 1.08 vs. 1.33 ± 0.38; p = 0.01), which suggests an increased responsivity of panic disorder patients to the adrenergic effects of yohimbine.

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KW - Spectral analysis-sympathetic

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Effects of yohimbine on heart rate variability in panic disorder patients and normal controls: A study of power spectral analysis of heart rate

Abstract

Keywords

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