TY - JOUR
T1 - Effects of weight loss intervention on erectile function in older men with type 2 diabetes in the Look AHEAD Trial
AU - Wing, Rena R.
AU - Rosen, Raymond C.
AU - Fava, Joseph L.
AU - Bahnson, Judy
AU - Brancati, Frederick
AU - Gendrano, Isaias Noel C.
AU - Kitabchi, Abbas
AU - Schneider, Stephen H.
AU - Wadden, Thomas A.
N1 - Funding Information:
Additional support was received from The Johns Hopkins Medical Institutions Bayview General Clinical Research Center (M01RR02719); the Massachusetts General Hospital Mallinckrodt General Clinical Research Center (M01RR01066); the University of Colorado Health Sciences Center General Clinical Research Center (M01RR00051) and Clinical Nutrition Research Unit (P30 DK48520); the University of Tennessee at Memphis General Clinical Research Center (M01RR0021140); the University of Pittsburgh General Clinical Research Center (M01RR000056 44) and NIH grant (DK 046204); and the University of Washington / VA Puget Sound Health Care System Medical Research Service, Department of Veterans Affairs; Frederic C. Bartter General Clinical Research Center (M01RR01346)
Funding Information:
The Sexual Dysfunction substudy of Look AHEAD was funded by a grant from the National Institutes of Health awarded to Dr. Raymond Rosen (R01 DK60438). The Look AHEAD study is supported by the Department of Health and Human Services through the following cooperative agreements from the National Institutes of Health: DK57136, DK57149, DK56990, DK57177, DK57171, DK57151, DK57182, DK57131, DK57002, DK57078, DK57154, DK57178, DK57219, DK57008, DK57135, and DK56992. The following federal agencies have contributed support: National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute of Nursing Research; National Center on Minority Health and Health Disparities; Office of Research on Women's Health; and the Centers for Disease Control and Prevention. This research was supported in part by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases.
PY - 2010/1
Y1 - 2010/1
N2 - Introduction: Overweight men with diabetes often report erectile dysfunction (ED), but few studies have examined effects of weight loss on this problem. Aim: This study examined 1-year changes in erectile function (EF) in overweight/obese men with type 2 diabetes participating in the Look AHEAD (Action for Health in Diabetes) trial. Methods: Participants in Look AHEAD were randomly assigned to a control condition involving diabetes support and education (DSE) or to intensive lifestyle intervention (ILI) involving group and individual sessions to reduce weight and increase physical activity. Men from five of the clinical sites in Look AHEAD completed the International Index of Erectile Function (IIEF) at baseline (N = 372) and at 1 year (N = 306) (82%). Main Outcome Measures: Changes in EF as reported on the EF subscale of the IIEF. Results: At 1 year, the ILI group lost a greater percent of initial body weight (9.9% vs. 0.6 %) and had greater improvements in fitness (22.7% vs. 4.6%) than DSE. EF improved more in ILI (17.3 ± 7.6 at baseline; 18.6 ± 8.1 at 1 year) than in DSE (18.3 ± 7.6 at baseline; 18.4 ± 8.0 at 1 year); P = 0.04 and P = 0.06 after adjusting for baseline differences. Using established norms for none (i.e., normal EF), and three grades (i.e., mild, moderate, and severe) ED, 8% of men in ILI reported a worsening of EF from baseline to 1 year, 70% stayed in the same category, and 22% reported improvements. In contrast, 20% of DSE reported worsening, 57% stayed in the same category, and 23% improved (P = 0.006). Conclusion: In this sample of older overweight/obese diabetic men, weight loss intervention was mildly helpful in maintaining EF.
AB - Introduction: Overweight men with diabetes often report erectile dysfunction (ED), but few studies have examined effects of weight loss on this problem. Aim: This study examined 1-year changes in erectile function (EF) in overweight/obese men with type 2 diabetes participating in the Look AHEAD (Action for Health in Diabetes) trial. Methods: Participants in Look AHEAD were randomly assigned to a control condition involving diabetes support and education (DSE) or to intensive lifestyle intervention (ILI) involving group and individual sessions to reduce weight and increase physical activity. Men from five of the clinical sites in Look AHEAD completed the International Index of Erectile Function (IIEF) at baseline (N = 372) and at 1 year (N = 306) (82%). Main Outcome Measures: Changes in EF as reported on the EF subscale of the IIEF. Results: At 1 year, the ILI group lost a greater percent of initial body weight (9.9% vs. 0.6 %) and had greater improvements in fitness (22.7% vs. 4.6%) than DSE. EF improved more in ILI (17.3 ± 7.6 at baseline; 18.6 ± 8.1 at 1 year) than in DSE (18.3 ± 7.6 at baseline; 18.4 ± 8.0 at 1 year); P = 0.04 and P = 0.06 after adjusting for baseline differences. Using established norms for none (i.e., normal EF), and three grades (i.e., mild, moderate, and severe) ED, 8% of men in ILI reported a worsening of EF from baseline to 1 year, 70% stayed in the same category, and 22% reported improvements. In contrast, 20% of DSE reported worsening, 57% stayed in the same category, and 23% improved (P = 0.006). Conclusion: In this sample of older overweight/obese diabetic men, weight loss intervention was mildly helpful in maintaining EF.
KW - Diabetes
KW - Fitness
KW - International index of erectile function (IIEF)
KW - Lifestyle
KW - Weight loss
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U2 - 10.1111/j.1743-6109.2009.01458.x
DO - 10.1111/j.1743-6109.2009.01458.x
M3 - Article
C2 - 19694925
AN - SCOPUS:74049088984
SN - 1743-6095
VL - 7
SP - 156
EP - 165
JO - Journal of Sexual Medicine
JF - Journal of Sexual Medicine
IS - 1 PART 1
ER -