Effects of vitamin A deficiency on the ocular surface

Research output: Contribution to journalArticle

Abstract

Vitamin A deficiency remains an important cause of ocular morbidity among patients with chronic liver disease and lipid malabsorption, and is a major cause of blindness in developing countries. Early ocular surface changes include keratinization of the conjunctiva and development of superficial punctate keratopathy. More severe deficiency results in corneal keratinization, ulceration, and necrosis. Vitamin A is necessary for normal differentiation of nonsquamous epithelium; keratinization is a direct consequence of its deficiency. Exposure exacerbates the process and surface phenomena, especially localized drying from loss of mucus-secreting goblet cells, reduced aqueous tear production, and irregularities of the keratinized surface may all contribute to stromal melting, which can occur in the absence of inflammatory infiltration or bacterial invasion. Surface abnormalities respond rapidly to systemic vitamin A. Significantly, corneal changes disappear long before the reappearance of goblet cells. Inflammation sometimes masks or reverses the xerotic process.

Original languageEnglish (US)
Pages (from-to)592-600
Number of pages9
JournalOphthalmology
Volume90
Issue number6
StatePublished - 1983

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Vitamin A Deficiency
Goblet Cells
Vitamin A
Conjunctiva
Blindness
Mucus
Masks
Tears
Freezing
Developing Countries
Liver Diseases
Chronic Disease
Necrosis
Epithelium
Inflammation
Morbidity
Lipids

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Effects of vitamin A deficiency on the ocular surface. / Sommer, Alfred.

In: Ophthalmology, Vol. 90, No. 6, 1983, p. 592-600.

Research output: Contribution to journalArticle

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