Effects of unilateral naris occlusion on the olfactory epithelium of adult mice

Kyung Shik Suh, So Yeun Kim, Yong Chul Bae, Gabriele V. Ronnett, Cheil Moon

Research output: Contribution to journalArticle

Abstract

Sensory stimulation is an essential component of neuronal functions, including information processing, dendritic and axonal refinement, synaptic plasticity, and neuronal survival. We examined the roles of sensory stimulation in the maintenance of olfactory sensory neurons in the olfactory epithelium using the adult mouse olfactory system as the model system. Obstruction of sensory stimulation through unilateral naris occlusion caused downregulation of proliferation and upregulation of apoptosis of neurons in the olfactory epithelium. Sensory stimulation is therefore important in maintaining homeostasis in the adult olfactory epithelium. Our study contributes to further understanding the roles and mechanisms of sensory stimulation in the postnatal neuronal development as well as to the damage and potential treatments of patients who suffer recurrent nasal obstruction.

Original languageEnglish (US)
Pages (from-to)1139-1142
Number of pages4
JournalNeuroReport
Volume17
Issue number11
DOIs
StatePublished - Jul 2006

Fingerprint

Olfactory Mucosa
Olfactory Receptor Neurons
Nasal Obstruction
Neuronal Plasticity
Automatic Data Processing
Homeostasis
Up-Regulation
Down-Regulation
Maintenance
Apoptosis
Neurons
Therapeutics

Keywords

  • Apoptosis
  • Deprivation
  • Naris
  • Occlusion
  • Olfactory
  • Survival

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Suh, K. S., Kim, S. Y., Bae, Y. C., Ronnett, G. V., & Moon, C. (2006). Effects of unilateral naris occlusion on the olfactory epithelium of adult mice. NeuroReport, 17(11), 1139-1142. https://doi.org/10.1097/01.wnr.0000224762.54336.7d

Effects of unilateral naris occlusion on the olfactory epithelium of adult mice. / Suh, Kyung Shik; Kim, So Yeun; Bae, Yong Chul; Ronnett, Gabriele V.; Moon, Cheil.

In: NeuroReport, Vol. 17, No. 11, 07.2006, p. 1139-1142.

Research output: Contribution to journalArticle

Suh, Kyung Shik ; Kim, So Yeun ; Bae, Yong Chul ; Ronnett, Gabriele V. ; Moon, Cheil. / Effects of unilateral naris occlusion on the olfactory epithelium of adult mice. In: NeuroReport. 2006 ; Vol. 17, No. 11. pp. 1139-1142.
@article{092e7b984a814202a51b8e0cb07b6a9a,
title = "Effects of unilateral naris occlusion on the olfactory epithelium of adult mice",
abstract = "Sensory stimulation is an essential component of neuronal functions, including information processing, dendritic and axonal refinement, synaptic plasticity, and neuronal survival. We examined the roles of sensory stimulation in the maintenance of olfactory sensory neurons in the olfactory epithelium using the adult mouse olfactory system as the model system. Obstruction of sensory stimulation through unilateral naris occlusion caused downregulation of proliferation and upregulation of apoptosis of neurons in the olfactory epithelium. Sensory stimulation is therefore important in maintaining homeostasis in the adult olfactory epithelium. Our study contributes to further understanding the roles and mechanisms of sensory stimulation in the postnatal neuronal development as well as to the damage and potential treatments of patients who suffer recurrent nasal obstruction.",
keywords = "Apoptosis, Deprivation, Naris, Occlusion, Olfactory, Survival",
author = "Suh, {Kyung Shik} and Kim, {So Yeun} and Bae, {Yong Chul} and Ronnett, {Gabriele V.} and Cheil Moon",
year = "2006",
month = "7",
doi = "10.1097/01.wnr.0000224762.54336.7d",
language = "English (US)",
volume = "17",
pages = "1139--1142",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams and Wilkins",
number = "11",

}

TY - JOUR

T1 - Effects of unilateral naris occlusion on the olfactory epithelium of adult mice

AU - Suh, Kyung Shik

AU - Kim, So Yeun

AU - Bae, Yong Chul

AU - Ronnett, Gabriele V.

AU - Moon, Cheil

PY - 2006/7

Y1 - 2006/7

N2 - Sensory stimulation is an essential component of neuronal functions, including information processing, dendritic and axonal refinement, synaptic plasticity, and neuronal survival. We examined the roles of sensory stimulation in the maintenance of olfactory sensory neurons in the olfactory epithelium using the adult mouse olfactory system as the model system. Obstruction of sensory stimulation through unilateral naris occlusion caused downregulation of proliferation and upregulation of apoptosis of neurons in the olfactory epithelium. Sensory stimulation is therefore important in maintaining homeostasis in the adult olfactory epithelium. Our study contributes to further understanding the roles and mechanisms of sensory stimulation in the postnatal neuronal development as well as to the damage and potential treatments of patients who suffer recurrent nasal obstruction.

AB - Sensory stimulation is an essential component of neuronal functions, including information processing, dendritic and axonal refinement, synaptic plasticity, and neuronal survival. We examined the roles of sensory stimulation in the maintenance of olfactory sensory neurons in the olfactory epithelium using the adult mouse olfactory system as the model system. Obstruction of sensory stimulation through unilateral naris occlusion caused downregulation of proliferation and upregulation of apoptosis of neurons in the olfactory epithelium. Sensory stimulation is therefore important in maintaining homeostasis in the adult olfactory epithelium. Our study contributes to further understanding the roles and mechanisms of sensory stimulation in the postnatal neuronal development as well as to the damage and potential treatments of patients who suffer recurrent nasal obstruction.

KW - Apoptosis

KW - Deprivation

KW - Naris

KW - Occlusion

KW - Olfactory

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=33745874086&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745874086&partnerID=8YFLogxK

U2 - 10.1097/01.wnr.0000224762.54336.7d

DO - 10.1097/01.wnr.0000224762.54336.7d

M3 - Article

C2 - 16837842

AN - SCOPUS:33745874086

VL - 17

SP - 1139

EP - 1142

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 11

ER -