TY - JOUR
T1 - Effects of triazolam on brain activity during episodic memory encoding
T2 - A PET study
AU - Mintzer, Miriam Z.
AU - Griffiths, Roland R.
AU - Contoreggi, Carlo
AU - Kimes, Alane S.
AU - London, Edythe D.
AU - Ernst, Monique
N1 - Funding Information:
This project was partially supported by National Institute on Drug Abuse Research Grants DA-03889 and DA-11936. The authors thank Sue Boyer, Jennifer Bragg, Andrew Horti, and Varughese Kurian for technical assistance, John Yingling for computer programming assistance and technical support, and Stephen Francis, John Matochik, and Tim Mudric for assistance with data analysis.
Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 2001
Y1 - 2001
N2 - It is well documented that acute administration of the benzodiazepine hypnotic drug triazolam (Halcion®) impairs episodic memory encoding. We examined the neuroanatomical substrates of this effect in healthy adult volunteers using a double-blind, within-subject design. Following oral capsule administration (0.25 mg/70 kg triazolam or placebo), regional cerebral blood flow (rCBF) was measured using positron emission tomography (PET) with 15O-H2O during the performance of semantic categorization, orthographic categorization, and visual fixation (resting) tasks. rCBF associated with episodic memory encoding was measured by the difference in rCBF during the orthographic categorization task relative to that during the semantic categorization task. Results in the placebo condition (n = 9) replicated those of previous nonpharmacological encoding studies (activation in the left prefrontal cortex, cerebellum, anterior cingulate cortex, temporal cortex, and occipital cortex). Relative to placebo, results in the triazolam condition (n = 6) revealed significantly impaired memory performance, and deactivation during encoding in a subset of areas shown previously to be associated with encoding (anterior cingulate cortex, cerebellum, and precuneus). Results are discussed in relation to triazolam's effects on mnemonic versus attentional processes.
AB - It is well documented that acute administration of the benzodiazepine hypnotic drug triazolam (Halcion®) impairs episodic memory encoding. We examined the neuroanatomical substrates of this effect in healthy adult volunteers using a double-blind, within-subject design. Following oral capsule administration (0.25 mg/70 kg triazolam or placebo), regional cerebral blood flow (rCBF) was measured using positron emission tomography (PET) with 15O-H2O during the performance of semantic categorization, orthographic categorization, and visual fixation (resting) tasks. rCBF associated with episodic memory encoding was measured by the difference in rCBF during the orthographic categorization task relative to that during the semantic categorization task. Results in the placebo condition (n = 9) replicated those of previous nonpharmacological encoding studies (activation in the left prefrontal cortex, cerebellum, anterior cingulate cortex, temporal cortex, and occipital cortex). Relative to placebo, results in the triazolam condition (n = 6) revealed significantly impaired memory performance, and deactivation during encoding in a subset of areas shown previously to be associated with encoding (anterior cingulate cortex, cerebellum, and precuneus). Results are discussed in relation to triazolam's effects on mnemonic versus attentional processes.
KW - Benzodiazepines
KW - Encoding
KW - Episodic memory
KW - Positron emission tomography
KW - Regional cerebral blood flow
KW - Triazolam
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U2 - 10.1016/S0893-133X(01)00280-9
DO - 10.1016/S0893-133X(01)00280-9
M3 - Article
C2 - 11682258
AN - SCOPUS:0034777637
SN - 0893-133X
VL - 25
SP - 744
EP - 756
JO - Neuropsychopharmacology
JF - Neuropsychopharmacology
IS - 5
ER -