Effects of treadmill exercise on transcranial magnetic stimulation-induced excitability to quadriceps after stroke

Larry W. Forrester, Daniel F Hanley, Richard F. Macko

Research output: Contribution to journalArticle

Abstract

Objective: To determine characteristics of transcranial magnetic stimulation (TMS)-induced measures of central motor excitability to the paretic and nonparetic quadriceps muscles of chronic hemiparetic stroke patients in the context of a short-term, submaximal bout treadmill exercise. Design: Cross-sectional. Setting: Motor control and gait biomechanics laboratory. Participants: Convenience sample of 11 patients including cohorts of treadmill untrained (n=8) and trained (n=3) stroke patients with chronic hemiparetic gait. Intervention: Short-term submaximal treadmill exercise. Main Outcome Measures: Thresholds, amplitudes and latencies of TMS-induced motor evoked potentials at vastus medialis in paretic and nonparetic lower extremities. Results: Baseline characteristics of the motor evoked potentials (MEPs) show significantly higher motor thresholds, longer latencies, and reduced amplitudes on the paretic side. In cross-sectional comparisons a group of treadmill-trained patients had greater paretic MEP amplitude changes after treadmill exercise versus paretic MEP responses from a group of untrained patients. Conclusions: These results indicate that treadmill training for 3 months or more may alter responsiveness of the lower-extremity central motor pathways to a short-term treadmill stimulus.

Original languageEnglish (US)
Pages (from-to)229-234
Number of pages6
JournalArchives of Physical Medicine and Rehabilitation
Volume87
Issue number2
DOIs
StatePublished - Feb 2006

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Transcranial Magnetic Stimulation
Motor Evoked Potentials
Stroke
Exercise
Quadriceps Muscle
Gait
Lower Extremity
Efferent Pathways
Biomechanical Phenomena
Outcome Assessment (Health Care)

Keywords

  • Evoked potentials, motor
  • Magnetics
  • Neuronal plasticity
  • Rehabilitation
  • Stroke
  • Treadmill test

ASJC Scopus subject areas

  • Rehabilitation

Cite this

Effects of treadmill exercise on transcranial magnetic stimulation-induced excitability to quadriceps after stroke. / Forrester, Larry W.; Hanley, Daniel F; Macko, Richard F.

In: Archives of Physical Medicine and Rehabilitation, Vol. 87, No. 2, 02.2006, p. 229-234.

Research output: Contribution to journalArticle

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