Effects of traumatic brain injury on cognitive functioning and cerebral metabolites in HIV-infected individuals

Kenny Lin; Michael J. Taylor; Robert Heaton; Donald Franklin; Terry Jernigan; Christine Fennema-Notestine; Allen McCutchan; J. Hampton Atkinson; Ronald J. Ellis; Justin McArthur; Susan Morgello; David Simpson; Ann C. Collier; Christina Marra; Benjamin Gelman; David Clifford; Igor Grant

doi:10.1080/13803395.2010.518140

Effects of traumatic brain injury on cognitive functioning and cerebral metabolites in HIV-infected individuals

Kenny Lin, Michael J. Taylor, Robert Heaton, Donald Franklin, Terry Jernigan, Christine Fennema-Notestine, Allen McCutchan, J. Hampton Atkinson, Ronald J. Ellis, Justin McArthur, Susan Morgello, David Simpson, Ann C. Collier, Christina Marra, Benjamin Gelman, David Clifford, Igor Grant

School of Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We explored the possible augmenting effect of traumatic brain injury (TBI) history on HIV (human immunodeficiency virus) associated neurocognitive complications. HIV-infected participants with self-reported history of definite TBI were compared to HIV patients without TBI history. Groups were equated for relevant demographic and HIV-associated characteristics. The TBI group evidenced significantly greater deficits in executive functioning and working memory. N-acetylaspartate, a putative marker of neuronal integrity, was significantly lower in the frontal gray matter and basal ganglia brain regions of the TBI group. Together, these results suggest an additional brain impact of TBI over that from HIV alone. One clinical implication is that HIV patients with TBI history may need to be monitored more closely for increased risk of HIV-associated neurocognitive disorder signs or symptoms.

Original language	English (US)
Pages (from-to)	326-334
Number of pages	9
Journal	Journal of Clinical and Experimental Neuropsychology
Volume	33
Issue number	3
DOIs	https://doi.org/10.1080/13803395.2010.518140
State	Published - Mar 2011

Keywords

HIV associated neurocognitive disorder
Head injury
Magnetic resonance spectroscopy
N-acetylaspartate
Neuropsychological performance

ASJC Scopus subject areas

Clinical Neurology
Neuropsychology and Physiological Psychology
Neurology
Clinical Psychology

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10.1080/13803395.2010.518140

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Lin, K., Taylor, M. J., Heaton, R., Franklin, D., Jernigan, T., Fennema-Notestine, C., McCutchan, A., Atkinson, J. H., Ellis, R. J., McArthur, J., Morgello, S., Simpson, D., Collier, A. C., Marra, C., Gelman, B., Clifford, D., & Grant, I. (2011). Effects of traumatic brain injury on cognitive functioning and cerebral metabolites in HIV-infected individuals. Journal of Clinical and Experimental Neuropsychology, 33(3), 326-334. https://doi.org/10.1080/13803395.2010.518140

Lin, K, Taylor, MJ, Heaton, R, Franklin, D, Jernigan, T, Fennema-Notestine, C, McCutchan, A, Atkinson, JH, Ellis, RJ, McArthur, J, Morgello, S, Simpson, D, Collier, AC, Marra, C, Gelman, B, Clifford, D & Grant, I 2011, 'Effects of traumatic brain injury on cognitive functioning and cerebral metabolites in HIV-infected individuals', Journal of Clinical and Experimental Neuropsychology, vol. 33, no. 3, pp. 326-334. https://doi.org/10.1080/13803395.2010.518140

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abstract = "We explored the possible augmenting effect of traumatic brain injury (TBI) history on HIV (human immunodeficiency virus) associated neurocognitive complications. HIV-infected participants with self-reported history of definite TBI were compared to HIV patients without TBI history. Groups were equated for relevant demographic and HIV-associated characteristics. The TBI group evidenced significantly greater deficits in executive functioning and working memory. N-acetylaspartate, a putative marker of neuronal integrity, was significantly lower in the frontal gray matter and basal ganglia brain regions of the TBI group. Together, these results suggest an additional brain impact of TBI over that from HIV alone. One clinical implication is that HIV patients with TBI history may need to be monitored more closely for increased risk of HIV-associated neurocognitive disorder signs or symptoms.",

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author = "Kenny Lin and Taylor, {Michael J.} and Robert Heaton and Donald Franklin and Terry Jernigan and Christine Fennema-Notestine and Allen McCutchan and Atkinson, {J. Hampton} and Ellis, {Ronald J.} and Justin McArthur and Susan Morgello and David Simpson and Collier, {Ann C.} and Christina Marra and Benjamin Gelman and David Clifford and Igor Grant",

note = "Funding Information: CNS HIV Antiretroviral Therapy Effects Research (CHARTER) is supported by award N01 MH22005 from the National Institutes of Health. Address correspondence to Igor Grant, Department of Psychiatry (0680), School of Medicine, University of California, San Diego, La Jolla, CA 92093–0680, USA (E-mail: igrant@ucsd.edu).",

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AU - Simpson, David

AU - Collier, Ann C.

AU - Marra, Christina

AU - Gelman, Benjamin

AU - Clifford, David

AU - Grant, Igor

N1 - Funding Information: CNS HIV Antiretroviral Therapy Effects Research (CHARTER) is supported by award N01 MH22005 from the National Institutes of Health. Address correspondence to Igor Grant, Department of Psychiatry (0680), School of Medicine, University of California, San Diego, La Jolla, CA 92093–0680, USA (E-mail: igrant@ucsd.edu).

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Effects of traumatic brain injury on cognitive functioning and cerebral metabolites in HIV-infected individuals

Abstract

Keywords

ASJC Scopus subject areas

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