Effects of Topical Flurbiprofen on the Intraocular Pressure Lowering Effects of Apraclonidine and Timolol

Michael E. Sulewski, Alan L. Robin, Howard L. Cummings, Lawrence M. Arkin

Research output: Contribution to journalArticle


We performed a prospective study that evaluated whether pretreatment with topical flurbiprofen alters the intraocular pressure (IOP) lowering effects of either topical 1% apraclonidine hydrochloride or 0.5% timolol maleate. Eighteen normal volunteers participated in this six-armed, randomized, double-masked, crossover study. All subjects received the first study medication, either bilateral 0.3% flurbiprofen or placebo (its vehicle), every 30 minutes for four applications. They next received the second study medication: either 0.5% timolol maleate (Timoptic), 1% apraclonidine hydrochloride, or placebo in both eyes. We measured IOP before the instillation of the first study medication and the second study medication (baseline), and then at 1, 3, and 6 hours later. All subjects underwent all six treatment arms. Flurbiprofen alone had no effect on IOP. Maximum IOP lowering occurred between 3 and 6 hours after timolol and apraclonidine administration. There was no difference in IOP lowering between timolol- and apraclonidine-treated eyes. Pretreatment with flurbiprofen did not affect the IOP lowering that was obtained with timolol or apraclonidine administration.

Original languageEnglish (US)
Pages (from-to)807-809
Number of pages3
JournalArchives of Ophthalmology
Issue number6
Publication statusPublished - 1991


ASJC Scopus subject areas

  • Ophthalmology

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