Effects of topical corticosteroids on human dermis

R. M. Lavker, N. M. Schechter, Gerald Sylvan Lazarus

Research output: Contribution to journalArticle

Abstract

The studies presented here establish that steroids have an effect on at least two of the cellular elements of the dermis: an inhibitory effect on the synthetic ability of fibroblasts which results in the depletion of ground substance and consequent reorganization of the fibrous elements, and a toxic effect on mast cells as evidenced by mast cell disappearance. This latter effect provides a reversible in vivo system to study correlations such as those described, as well as to further study the biology of the mast cell. Furthermore, aggressive treatment with topical steroids of mast cell-dependent disorders may have a role in appropriately severe cutaneous disease states.

Original languageEnglish (US)
Pages (from-to)101-107
Number of pages7
JournalBritish Journal of Dermatology
Volume115
Issue numberSUPPL. 31
StatePublished - 1986
Externally publishedYes

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Dermis
Mast Cells
Adrenal Cortex Hormones
Steroids
Poisons
Skin Diseases
Fibroblasts

ASJC Scopus subject areas

  • Dermatology

Cite this

Lavker, R. M., Schechter, N. M., & Lazarus, G. S. (1986). Effects of topical corticosteroids on human dermis. British Journal of Dermatology, 115(SUPPL. 31), 101-107.

Effects of topical corticosteroids on human dermis. / Lavker, R. M.; Schechter, N. M.; Lazarus, Gerald Sylvan.

In: British Journal of Dermatology, Vol. 115, No. SUPPL. 31, 1986, p. 101-107.

Research output: Contribution to journalArticle

Lavker, RM, Schechter, NM & Lazarus, GS 1986, 'Effects of topical corticosteroids on human dermis', British Journal of Dermatology, vol. 115, no. SUPPL. 31, pp. 101-107.
Lavker, R. M. ; Schechter, N. M. ; Lazarus, Gerald Sylvan. / Effects of topical corticosteroids on human dermis. In: British Journal of Dermatology. 1986 ; Vol. 115, No. SUPPL. 31. pp. 101-107.
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