Effects of THIP on chronic anxiety

Research output: Contribution to journalArticle

Abstract

The effects of THIP, a GABA agonist, were examined in patients with anxiety disorders. Eight patients were prescribed THIP (5-20 mg) to be taken three times a day for 2 weeks in a single-blind study, with placebo conditions preceding and following the active drug period. Anxiety ratings significantly decreased on several measures during active drug treatment and increased again with placebo administration. However, the anxiolytic effects of THIP appeared to be weak and occurred at, or close to dose levels which induced sedation and undesirable side effects. As with other GABA agonists and GABA-mimetic drugs, side effects included giddiness, depersonalization, poor concentration, and transitory delirious states, suggesting that excessive stimulation of the GABAergic system may disrupt normal brain functioning.

Original languageEnglish (US)
Pages (from-to)338-341
Number of pages4
JournalPsychopharmacology
Volume80
Issue number4
DOIs
StatePublished - Jul 1983

Fingerprint

GABA Agonists
Anxiety
Placebos
Depersonalization
Single-Blind Method
Anti-Anxiety Agents
Dizziness
Anxiety Disorders
Drug-Related Side Effects and Adverse Reactions
Pharmaceutical Preparations
gamma-Aminobutyric Acid
Brain
gaboxadol
Therapeutics

Keywords

  • Anxiolytics
  • GABA
  • GABA agonists
  • THIP

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effects of THIP on chronic anxiety. / Hoehn-Saric, Rudolf.

In: Psychopharmacology, Vol. 80, No. 4, 07.1983, p. 338-341.

Research output: Contribution to journalArticle

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