Effects of the type of embolization particles on carboplatin concentration in liver tumors after transcatheter arterial chemoembolization in a rabbit model of liver cancer

Kelvin Hong, Hisham Kobeiter, Christos S Georgiades, Michael S. Torbenson, Jean Francois H Geschwind

Research output: Contribution to journalArticle

Abstract

PURPOSE: To study the effect of particle type used during transarterial hepatic chemoembolization (TACE) on carboplatin concentration after TACE in an animal model of liver cancer (VX2) and to determine the concentration of carboplatin within tumor, liver, and plasma. MATERIALS AND METHODS: The VX2 tumors were grown in the livers of 23 rabbits. Carboplatin (5 mg/kg) was selected because of its known potency against VX2 tumor. Group 1 was treated with TACE with tris-acryl gelatin microspheres (100-300 μm), group 2 was treated with TACE with polyvinyl alcohol (PVA; 150-250 μm), group 3 (control) was treated with intraarterial saline solution, and group 4 (pharmacokinetic) was treated with intraarterial carboplatin. Animals were killed after 48 hours, and concentrations of carboplatin were measured by atomic absorption spectroscopy from samples of blood and liver (central and peripheral zones of tumor and nontumorous liver tissue). RESULTS: In group 1 (tris-acryl gelatin microspheres) and group 2 (PVA), the mean carboplatin concentrations were 117 μg/g and 31.8 μg/g, respectively, within the central zone of the tumor and 38.5 μg/g versus 7.9 μg/g, respectively, in the peripheral zone. No carboplatin was detected in nontumorous liver tissue and plasma concentrations were low in both treated groups (

Original languageEnglish (US)
Pages (from-to)1711-1717
Number of pages7
JournalJournal of Vascular and Interventional Radiology
Volume16
Issue number12
DOIs
StatePublished - Dec 2005

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Carboplatin
Liver Neoplasms
Rabbits
Liver
Neoplasms
Polyvinyl Alcohol
Sodium Chloride
Spectrum Analysis
Animal Models
Pharmacokinetics
Control Groups

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Effects of the type of embolization particles on carboplatin concentration in liver tumors after transcatheter arterial chemoembolization in a rabbit model of liver cancer. / Hong, Kelvin; Kobeiter, Hisham; Georgiades, Christos S; Torbenson, Michael S.; Geschwind, Jean Francois H.

In: Journal of Vascular and Interventional Radiology, Vol. 16, No. 12, 12.2005, p. 1711-1717.

Research output: Contribution to journalArticle

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abstract = "PURPOSE: To study the effect of particle type used during transarterial hepatic chemoembolization (TACE) on carboplatin concentration after TACE in an animal model of liver cancer (VX2) and to determine the concentration of carboplatin within tumor, liver, and plasma. MATERIALS AND METHODS: The VX2 tumors were grown in the livers of 23 rabbits. Carboplatin (5 mg/kg) was selected because of its known potency against VX2 tumor. Group 1 was treated with TACE with tris-acryl gelatin microspheres (100-300 μm), group 2 was treated with TACE with polyvinyl alcohol (PVA; 150-250 μm), group 3 (control) was treated with intraarterial saline solution, and group 4 (pharmacokinetic) was treated with intraarterial carboplatin. Animals were killed after 48 hours, and concentrations of carboplatin were measured by atomic absorption spectroscopy from samples of blood and liver (central and peripheral zones of tumor and nontumorous liver tissue). RESULTS: In group 1 (tris-acryl gelatin microspheres) and group 2 (PVA), the mean carboplatin concentrations were 117 μg/g and 31.8 μg/g, respectively, within the central zone of the tumor and 38.5 μg/g versus 7.9 μg/g, respectively, in the peripheral zone. No carboplatin was detected in nontumorous liver tissue and plasma concentrations were low in both treated groups (",
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AU - Geschwind, Jean Francois H

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N2 - PURPOSE: To study the effect of particle type used during transarterial hepatic chemoembolization (TACE) on carboplatin concentration after TACE in an animal model of liver cancer (VX2) and to determine the concentration of carboplatin within tumor, liver, and plasma. MATERIALS AND METHODS: The VX2 tumors were grown in the livers of 23 rabbits. Carboplatin (5 mg/kg) was selected because of its known potency against VX2 tumor. Group 1 was treated with TACE with tris-acryl gelatin microspheres (100-300 μm), group 2 was treated with TACE with polyvinyl alcohol (PVA; 150-250 μm), group 3 (control) was treated with intraarterial saline solution, and group 4 (pharmacokinetic) was treated with intraarterial carboplatin. Animals were killed after 48 hours, and concentrations of carboplatin were measured by atomic absorption spectroscopy from samples of blood and liver (central and peripheral zones of tumor and nontumorous liver tissue). RESULTS: In group 1 (tris-acryl gelatin microspheres) and group 2 (PVA), the mean carboplatin concentrations were 117 μg/g and 31.8 μg/g, respectively, within the central zone of the tumor and 38.5 μg/g versus 7.9 μg/g, respectively, in the peripheral zone. No carboplatin was detected in nontumorous liver tissue and plasma concentrations were low in both treated groups (

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